研究開発

センター長・教授

小室 一成

Pubmed

https://pubmed.ncbi.nlm.nih.gov/?term=komuro+issei&sort=date

Researchmap

https://researchmap.jp/komuro-try

主要論文

• Hiroi Y, Kudoh S, Monzen K, Ikeda Y, Yazaki Y, Nagai R, Komuro I. Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation. Nat Genet 28: 276- 280, 2001.
  https://doi.org/10.1038/90123
• Zou Y, Akazawa H, Qin Y, Sano M, Takano H, Minamino T, Makita N, Iwanaga K, Zhu W, Kudoh S, Toko H, Tamura K, Kihara M, Nagai T, Fukamizu A, Umemura S, Iiri T, Fujita T, Komuro I. Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II. Nat Cell Biol 6: 499-506, 2004.
  https://doi.org/10.1038/90123
• Harada M, Qin Y, Takano H, Minamino T, Zou Y, Toko H, Ohtsuka M, Matsuura K, Sano M, Nishi J, Akazawa H, Kunieda T, Zhu W, Hasegawa H, Kunisada K, Nagai T, Nakaya H, Yamauchi-Takihara K, Komuro I. G-CSF prevents cardiac remodeling after myocardial infarction by activating Jak/Stat in cardiomyocytes. Nat Med 11: 305-311, 2005.
  https://doi.org/10.1038/nm1199
• Sano M, Minamino T, Toko H, Miyauchi H, Orimo M, Qin Y, Akazawa H, Tateno K, Kayama Y, Harada M, Shimizu I, Asahara T, Hamada H, Tomita S, Molkentin J.D, Zou Y, Komuro I. p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload. Nature 446: 444-448, 2007.
  https://doi.org/10.1038/nature05602
• Monzen K, Ito Y, Naito A.T, Kasai H, Hiroi Y, Hayashi D, Shiojima I, Yamazaki T, Miyazono K, Asashima, M., Nagai, R., Komuro, I. A crucial role of a high mobility group protein HMGA2 in cardiogenesis. Nat Cell Biol 10: 567-574, 2008.
  https://doi.org/10.1038/ncb1719
• Zhu W, Shiojima I, Ito Y, Li Z, Ikeda H, Yoshida M, Naito A.T, Nishi J.I, Ueno H, Umezawa A, Minamino T, Nagai T, Kikuchi A, Asashima M, Komuro I. IGFBP-4 is an inhibitor of canonical Wnt signaling required for cardiogenesis. Nature 454: 345-349, 2008.
  https://doi.org/10.1038/nature07027
• Minamino T, Orimo M, Shimizu I, Kunieda T, Yokoyama M, Ito T, Nojima A, Nabetani A, Oike Y, Matsubara H, Ishikawa F, Komuro I. A crucial role for adipose tissue p53 in the regulation of insulin resistance. Nat Med 15: 1082-1087, 2009.
  https://doi.org/10.1038/nm.2014
• Naito AT, Sumida T, Nomura S, Liu ML, Higo T, Nakagawa A, Okada K, Sakai T, Hashimoto A, Hara Y, Shimizu I, Zhu W, Toko H, Katada A, Akazawa H, Oka T, Lee JK, Minamino T, Nagai T, Walsh K, Kikuchi A, Matsumoto M, Botto M, Shiojima I, Komuro I. Complement C1q activates canonical Wnt signaling and promotes aging-related phenotypes. Cell 149:1298-1313,2012.
  https://doi.org/10.1016/j.cell.2012.03.047
• Koyama S, Ito K, Terao C, Akiyama M, Horikoshi M, Momozawa Y, Matsunaga H, Ieki H, Ozaki K, Onouchi Y, Takahashi A, Nomura S, Morita H, Akazawa H, Kim C, Seo JS, Higasa K, Iwasaki M, Yamaji T, Sawada N, Tsugane S, Koyama T, Ikezaki H, Takashima N, Tanaka K, Arisawa K, Kuriki K, Naito M, Wakai K, Suna S, Sakata Y, Sato H, Hori M, Sakata Y, Matsuda K, Murakami Y, Aburatani H, Kubo M, Matsuda F, Kamatani Y, Komuro I. Population-specific and trans-ancestry genome-wide analyses identify distinct and shared genetic risk loci for coronary artery disease. Nat Genet 52: 1169-1177, 2020. Epub 2020 Oct 5. PMID: 33020668
• Miyazawa K, Ito K, Ito M, Zou Z, Kubota M, Nomura S, Matsunaga H, Koyama S, Ieki H, Akiyama M, Koike Y, Kurosawa R, Yoshida H, Ozaki K, Onouchi Y, BioBank Japan P, Takahashi A, Matsuda K, Murakami Y, Aburatani H, Kubo M, Momozawa Y, Terao C, Oki S, Akazawa H, Kamatani Y, Komuro I. Cross-ancestry genome-wide analysis of atrial fibrillation unveils disease biology and enables cardioembolic risk prediction. Nat Genet 55: 187-197, 2023.
  https://doi.org/10.1038/s41588-022-01284-9

准教授

上田 和孝

Pubmed

https://www.ncbi.nlm.nih.gov/myncbi/kazutaka.ueda.1/bibliography/public/

Researchmap

https://researchmap.jp/kazutakaueda

主要論文

• Ueda K, Takano H, Hasegawa H, Niitsuma Y, Qin Y, Ohtsuka M, Komuro I. Granulocyte colony-stimulating factor directly inhibits myocardial ischemia-reperfusion injury through Akt-endothelial NO synthase pathway. Arteriosclerosis, Thrombosis, and Vascular Biology. 26:108-13, 2006
• Ueda K, Takano H, Niitsuma Y, Hasegawa H, Uchiyama R, Oka T, Miyazaki M, Nakaya H & Komuro I. Sonic hedgehog is a critical mediator of erythropoietin-induced cardiac protection. Journal of Clinical Investigation. 120:2016-2029, 2010
• Ueda K, Lu Q, Baur W, Aronovitz MJ, Karas RH. Rapid estrogen receptor signaling mediates estrogen-induced inhibition of vascular smooth muscle cell proliferation. Arteriosclerosis, Thrombosis, and Vascular Biology. 33, 1837-1843, 2013
• Ueda K^*, Kasao M, Shimamura M, Haruta H, Nitta S, Kaneko M, Uemura Y, Morita H, Komuro I, Shirai T. Impact of Oral Treatment on Physical Function in Older Patients Hospitalized for Heart Failure: A Randomized Clinical Trial. PLOS ONE. 11(12): e0167933, 2016
• Ueda K, Takimoto E, Lu Q, Liu P, Fukuma N, Adachi Y, Suzuki R, Chou S, Baur W, Aronovitz MJ, Greenberg AS, Komuro I, Karas RH. Membrane-Initiated Estrogen Receptor Signaling Mediates Metabolic Homeostasis via Central Activation of Protein Phosphatase 2A. Diabetes. 67(8):1524-1537, 2018.
• Kaneko M, Ueda K^*, Nishimae I, Nitta S, Suzuki M, Kasao M, Shirai T. Subendocardial ischemia due to coronary artery spasm causes transient severe mitral regurgitation. Circulation-Heart Failure. 11:e0054962018, 2018.
• Ueda K, Adachi Y, Liu P, Fukuma N, Takimoto E. Regulatory actions of estrogen receptor signaling in the cardiovascular system. Frontiers in Endocrinology. 10:909, 2020.
• Adachi Y, Ueda K^*, Nomura S, Ito K, Katoh M, Katagiri M, Yamada S, Hashimoto M, Zhai B, Numata G, Otani A, Hinata M, Hiraike Y, Waki H, Takeda N, Morita H, Ushiku T, Yamauchi T, Takimoto E, Komuro I. Beiging of perivascular adipose tissue regulates its inflammation and vascular remodeling. Nature Communications, 13(1):5117, 2022.
• Adachi Y, Ueda K^*, Takimoto E. Perivascular Adipose Tissue in Vascular Pathologies - Novel Therapeutic Target for Atherosclerotic Disease? Frontiers in Cardiovascular Medicine, 10, 2023
• Kaneko M, Kasao M, Obikane H, Ueda K*. Critical heart failure associated with beta-blocker-induced cardiac phospholipidosis: a case report. European Heart Journal-Case Reports, 8(12), 2024

*corresponding author

教授（国際医療福祉大学三田病院）

田村 雄一

講師（国際医療福祉大学三田病院）

磯部 更紗

Pubmed

https://www.ncbi.nlm.nih.gov/myncbi/1xOorVB5qkl5pu/bibliography/public/

Researchmap

https://researchmap.jp/sarasa.isobe

主要論文

• Isobe S, Nair RV, Kang HY, Wang L, Moonen JR, Shinohara T, Cao A, Taylor S, Otsuki S, Marciano DP, Harper RL, Adil MS, Zhang C, Lago-Docampo M, Körbelin J, Engreitz JM, Snyder MP, Rabinovitch M. Reduced FOXF1 links unrepaired DNA damage to pulmonary arterial hypertension. Nat Commun. 2023 Nov 21;14(1):7578. doi: 10.1038/s41467-023-43039-y. PubMed PMID: 37989727; PubMed Central PMCID: PMC10663616.
• Taylor S*, Isobe S*, Cao A, Contrepois K, Benayoun BA, Jiang L, Wang L, Melemenidis S, Ozen MO, Otsuki S, Shinohara T, Sweatt AJ, Kaplan J, Moonen JR, Marciano DP, Gu M, Miyagawa K, Hayes B, Sierra RG, Kupitz CJ, Del Rosario PA, Hsi A, Thompson AAR, Ariza ME, Demirci U, Zamanian RT, Haddad F, Nicolls MR, Snyder MP, Rabinovitch M. Endogenous Retroviral Elements Generate Pathologic Neutrophils in Pulmonary Arterial Hypertension. Am J Respir Crit Care Med.2022 Oct 15;206(8):1019-1034. doi: 10.1164/rccm.202102-0446OC. PubMed PMID: 35696338; PubMed Central PMCID: PMC9801997. *Co-first author.
• Isobe S, Kataoka M, Endo J, Moriyama H, Okazaki S, Tsuchihashi K, Katsumata Y, Yamamoto T, Shirakawa K, Yoshida N, Shimoda M, Chiba T, Masuko T, Hakamata Y, Kobayashi E, Saya H, Fukuda K, Sano M. Endothelial-Mesenchymal Transition Drives Expression of CD44 Variant and xCT in Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2019 Sep;61(3):367-379. doi: 10.1165/rcmb.2018-0231OC. PubMed PMID: 30897333.
• Isobe S, Itabashi Y, Kawakami T, Kataoka M, Kohsaka S, Tsugu T, Kimura M, Sawano M, Katsuki T, Kohno T, Endo J, Murata M, Fukuda K. Increasing mixed venous oxygen saturation is a predictor of improved renal function after balloon pulmonary angioplasty in patients with chronic thromboembolic pulmonary hypertension. Heart Vessels. 2019 Apr;34(4):688-697. doi: 10.1007/s00380-018-1284-4. Epub 2018 Nov 1. PubMed PMID: 30386916.
• Isobe S, Kataoka M, Aimi Y, Gamou S, Satoh T, Fukuda K. Improved Survival of Patients with Pulmonary Arterial Hypertension with BMPR2 Mutations in the Last Decade. Am J Respir Crit Care Med. 2016 Jun 1;193(11):1310-4. doi: 10.1164/rccm.201601-0158LE. PubMed PMID: 27248591.