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河上 裕

河上 裕
(かわかみ ゆたか)教授

医学研究科 医学専攻
所属キャンパス: 成田キャンパス

略歴

慶應義塾大学医学部卒業 博士(医学)、慶應義塾大学名誉教授・特任教授 慶應義塾大学血液感染リウマチ内科助手(総合内科専門医)、米国南フロリダ大学、カリフォルニア工科大学、NIH国立がん研究所留学、慶應義塾大学医学部先端医科学研究所所長・教授、慶應義塾大学医学研究科委員長などを歴任. 日本がん免疫学会理事長、日本癌学会理事、日本臨床免疫学会理事、日本学術会議連携会員、 2005年Thomson ISI highly cited researcher、SGH特別賞、2006年慶應義塾大学医学部三四会北里賞、2018年慶應義塾大学義塾賞、日本免疫学会ヒト免疫研究賞

学位

博士(医学)(慶應義塾大学)

専門分野

免疫学、腫瘍学、内科学

研究指導テーマ

がんなど各種ヒト疾患の免疫病態の解明と制御法の開発

私たちは、がんなど各種ヒト疾患の免疫病態の理解により、新しい診断・治療・予防法の開発を目指しています。最近は、患者さんごとに異なるがんの免疫病態の機序解明とその制御法(免疫チェックポイント阻害薬を用いた複合免疫療法や遺伝子改変T細胞療法など)の開発を進めています。最新技術を駆使して臨床検体とマウスモデルを用いた研究により、さまざまな課題の解決を試みています。

大学院入学希望者に望むこと

免疫は本当に多くの病気の病態に深く関与しています。私たちが特に研究を進めているがんの免疫病態は多様でがん治療の反応性に関係します。明確な治療効果を示す免疫チェックポイント阻害薬治療症例の各種新技術を駆使した解析、さらに広く疾患横断的・異分野連携による免疫病態の解析はヒト免疫学を発展させ、新しい診断・治療・予防法の開発につながります。多様な視点・手法で、知恵を絞って、疾患の免疫病態解明と臨床応用を目指した研究に参画してくれる若手研究者に期待しています。

研究業績

【researchmap】
https://researchmap.jp/read0162114


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  9. 9. Yaguchi T, Kobayashi A, Inozume T, et al. Human PBMC transferred murine MHC class I/II deficient NOG mice enable long-term evaluation of human immune responses. Cell Mol Immunol. 14:1, 2017
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  11. 11. Yaguchi T, Goto Y, Kido K, et al, Immune suppression and resistance mediated by constitutive activation of Wnt/β-catenin signaling in human melanoma cells. J Immunol, 189:2110,2012
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  13. 13. Ueda R, Ohkusu-Tsukada K, Fusaki N, et al. Identification of HLA-A2- and A24-restricted T-cell epitopes derived from SOX6 expressed in glioma stem cells for immunotherapy. Int J Cancer. 126:919,2010
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  15. 15. Asahi A, Nishimoto T, Okazaki Y, et al. Helicobacter pylori eradication shifts monocytes' Fcγ receptor balance toward inhibitory Fc γ RIIB in immune thrombocytopenic purpura. J Clin Invest. 118: 2939, 2008
  16. 16. Sumimoto H, Imabayashi F, Iwata T, et al. The BRAF-MAPK signaling pathway is essential for cancer immune evasion in human melanoma cells. J Exp Med, 203:1651,2006
  17. 17. Kuwana M, Matsuura E, Kobayashi K, et al. Binding of β2-glycoprotein I to anionic phospholipids facilitates processing and presentation of a cryptic epitope that activates pathogenic autoreactive T cells. Blood. 105:1552,2005
  18. 18. Kuwana M, Okazaki Y, Yasuoka H, et al. Defective vasculogenesis in systemic sclerosis. Lancet. 364:603,2004
  19. 19. Sumimoto H, Miyagishi M, Miyoshi H, et al. Inhibition of growth and invasive ability of melanoma by inactivation of mutated BRAF with lentivirus-mediated RNA interference. Oncogene. 23: 6031,2004
  20. 20. Ishikawa T, Fujita T, Suzuki Y, et al. Tumor-specific Immunological Recognition of Frameshift-mutated Peptides in Colon Cancer with Microsatellite Instability. Cancer Res. 63:5564, 2003
  21. 21. Toda M, Iizuka Y, Kawase T, et al. Immuno-Viral Therapy of Brain Tumors by Combination of Viral Therapy with Cancer Vaccination Using a Replication-Conditional HSV. Cancer Gene Ther.9:356, 2002
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  24. 24. Robbins PF, El-Gamil M, Li YF, et al. A mutated b-catenin gene encodes a melanoma - specific antigen recognized by tumor infiltrating lymphocytes. J Exp Med. 183:1185, 1996.
  25. 25. Kawakami Y, Eliyahu S, Delgado CH, et al. Identification of human melanoma antigen recognized by tumor infiltrating lymphocytes associated with in vivo tumor rejection. Proc Natl Acad Sci USA, 91:6458, 1994.
  26. 26. Kawakami Y, Eliyahu S, Delgado CH, et al, Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor. Proc Natl Acad SciUSA, 91:3515, 1994

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