教員紹介 TEACHING STAFF
教員情報
北川 元生
(きたがわ もとお)教授
医学研究科 医学専攻
所属キャンパス: 成田キャンパス
略歴
千葉大学大学院医学研究院准教授、Yale University Postdoctoral Associate、東京大学助手、学術振興会特別研究員
学位
博士(医学)(東北大学)
専門分野
生化学、分子生物学
大学院入学希望者に望むこと
タンパク質の高次構造、機能から、マウスを用いた生体内での役割の解析までをおこなう研究室をつくります。また異なった専門をもつ国内外の研究者との共同研究を積極的におこないます。テーマであるNotchシグナルは、細胞分化、発生を制御するとともに、がんをはじめとする各種疾患での役割が注目されているシステムです。研究に参画する大学院生を求めます。
研究業績
【researchmap】
https://researchmap.jp/read0055497
<代表論文>
- 1. Masuda W., Yamakawa T., Ajima R., Miyake K., Umemiya T., Azuma K., Tamaru J.-i., Kiso M., Das P., Saga Y., Matsuno K., Kitagawa M.
TM2D3, a mammalian homologue of Drosophila neurogenic gene product Almondex, regulates surface presentation of Notch receptors.
Sci. Rep. 13, 20913, 2023. doi:10.1038/s41598-023-46866-7 - 2. Masuda, et al. Enhanced surface presentation and activation of Notch1 by transmembrane 2 domain containing 3, a mammalian homologue of Drosophila neurogenic gene product Almondex. Submitted.
- 3. Toritsuka, et al. Regulation of striatal dopamine responsiveness by Notch/RBP-J signaling. Transl. Psychiatry 7, e1049,2017
- 4. Kitagawa M. Notch signaling in the nucleus: roles of Mastermind-like transcriptional coactivators. J. Biochem. 159, 287-294, 2016
- 5. Muroyama, et al. Olfactory sensory neurons control dendritic complexity of mitral cells via Notch signaling. PLOS Genet. 12, e1006514, 2016.
- 6. Watanabe, et al. MAML1 enhances the transcriptional activity of Runx2 and plays a role in bone development. PLOS Genet. 9, e1003132, 2013.
- 7. Oyama, et al. Mastermind-like 1 (MamL1) and mastermind-like 3 (MamL3) are essential for Notch signaling in vivo. Development 138, 5235-5246, 2011
- 8. Köchert, et al. High-level expression of Mastermind-like 2 contributes to aberrant activation of the NOTCH signaling pathway in human lymphomas. Oncogene 30, 1831-1840, 2011
- 9. Sasaki, et al. The repression of Notch signaling occurs via the destabilization of mastermind-like 1 by Mesp2 and is essential for somitogenesis. Development 138, 55-64, 2011.
- 10. Ishitani, et al. Nemo-like kinase suppresses Notch signalling by interfering with formation of the Notch active transcriptional complex. Nature Cell Biol. 12, 278-285, 2010.
- 11. Fukami, et al. Mastermind-like domain containing 1 (MAMLD1 or CXorf6) transactivates the Hes3 promoter, augments testosterone production, and contains the SF1 target sequence. J. Biol. Chem. 283, 5525-5532, 2008
- 12. Oyama, et al. Mastermind-1 is required for Notch signal-dependent steps in lymphocyte development in vivo. Proc. Natl. Acad. Sci. U.S.A. 104, 9764-9769, 2007
- 13. Ishikawa, et al. Notch deficiency implicated in the pathogenesis of congenital disorder of glycosylation IIc. Proc. Natl. Acad. Sci. U.S.A. 102, 18532-18537, 2005.
- 14. Sasamura, et al. Neurotic, a novel maternal neurogenic gene, encodes an O-fucosyltransferase that is essential for Notch–Delta interactions. Development 130, 4785-4795, 2003
- 15. Lin, et al. Identification of new human mastermind proteins defines a family that consists of positive regulators for Notch signaling. J. Biol. Chem. 277, 50612-50620, 2002.
- 16. Kitagawa, et al. A human protein with sequence similarity to Drosophila Mastermind coordinates the nuclear form of Notch and a CSL protein to build a transcriptional activator complex on target promoters. Mol. Cell. Biol. 21, 4337-4346, 2001
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