国際医療福祉大学大学院

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教員情報

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藤井 克則
（ふじい かつのり）教授

医学研究科 医学専攻
所属キャンパス： 成田キャンパス

略歴

千葉大学医学部卒業、元千葉大学大学院医学研究院小児病態学講師、エモリー大学薬学部留学、千葉大学医学部附属病院移行期医療センター前副センター長、前千葉大学大学院医学研究院小児病態学准教授、千葉大学大学院医学研究院特任教授

学位

博士（医学）（千葉大学）

専門分野

小児科学、分子遺伝学、シグナル伝達、ヘッジホッグ関連疾患、再生医療、腫瘍学、創薬スクリーニング、臨床小児神経学

大学院入学希望者に望むこと

小児科学は遺伝学の最前線であり、増殖シグナルの遺伝子変異は形態形成と発癌に直結します。本研究では疾患iPS細胞を用いてシグナル異常が疾患発生の病態機序を明らかにし、治療学として創薬スクリーニングを行い新たな治療戦略を考案します。また小児科臨床において小児神経学、小児循環器学、小児アレルギー学の特定臨床研究を進めます。分子標的治療の時代においてチャレンジ精神に富む大学院生を広く求めます。

自身の研究テーマ

形態形成研究、ヘッジホッグシグナル研究、Gorlin症候群由来iPS細胞研究、再生医療、創薬スクリーニング、小児特定臨床研究（神経・循環器・アレルギー）

研究業績

【researchmap】
https://researchmap.jp/read0206295/


  1. Konda Y, Mihira H, Akiyama L, Shiko Y, Ozawa Y, Kawasaki Y, Fujii K, Hiramoto R. Patient background related to success and adverse event in pediatric sedated MRI. (in press)
  2. Sawada D, Ito A, Shiohama T, Tsukada H, Fujii K. Spontaneous spinal cord infarction in a 10-year-old Japanese girl. Pediatr Int (in press).
  3. Sawada D, Naito S, Aoyama H, Shiohama T, Ichikawa T, Imagawa E, Miyake N, Matsumoto N, Fujii K. Remitting and exacerbating white matter lesions in leukoencephalopathy with thalamus and brainstem involvement and high lactate. Brain Dev. 43:798-803, 2021.
  4. Yoshii S, Shibuya K, Yokota H, Ikehara H, Shiohama T, Sawada D, Kuwabara S, Fujii K. Magnetic resonance neurography in diagnosing childhood chronic inflammatory demyelinating polyradiculoneuropathy. Brain Dev. 43: 352-356, 2021.
  5. Koga Y, Povalko N, Inoue E, Ishii A, Fujii K, Fujii T, Murayama K, Mogami Y, Hata I, Ikawa M, Fukami K, Fukumoto Y, Nomura M, Ichikawa K, Yoshida K. A new diagnostic indication device of a biomarker growth differentiation factor 15 for mitochondrial diseases: From laboratory to automated inspection. J Inherit Metab Dis. 44: 358-366, 2021.
  6. Uchikawa H, Fujii K, Shiohama T, Nakazato M, Shimizu E, Miyashita T, Shimojo N. Specific temperament in patients with nevoid basal cell carcinoma syndrome. Pediatr Int. 63: 177-182, 2021.
  7. Ikehara H, Fujii K, Miyashita T, Ikemoto Y, Nagamine M, Shimojo N, Umezawa A. Establishment of a Gorlin syndrome model from induced neural progenitor cells with constitutive active GLI1 expression and higher sensitivity to SMO inhibition. Lab Invest. 100:657-664, 2020.
  8. Ikemoto Y, Miyashita T, Nasu M, Hatsuse H, Kajiwara K, Fujii K, Motojima T, Kokido I, Toyoda M, Umezawa A. Gorlin syndrome-induced pluripotent stem cells form medulloblastoma with loss of heterozygosity in PTCH1. Aging. 12: 9935-9947, 2020.
  9. Takeuchi N, Ohkusu M, Hishiki H, Fujii K, Hotta M, Murata S, Ishiwada N. First report on multidrug-resistant non-encapsulated Streptococcus pneumoniae isolated from a patient with pneumonia. J Infect Chemotherapy. 26: 749-751, 2020.
  10. Sanz-Morello B, Pfisterer U, Winther Hansen N, Demharter S, Thakur A, Fujii K, Levitskii SA, Montalant A, Korshunova I, Mammen PP, Kamenski P, Noguchi S, Aldana BI, Hougaard KS, Perrier JF, Khodosevich K. Complex IV subunit isoform COX6A2 protects fast-spiking interneurons from oxidative stress and supports their function. EMBO J. 39: e105759, 2020.
  11. Omata T, Fukui K, Kodama K, Watanabe Y, Aoyama H, Fujii K, Shimojo N. Ocular myasthenia gravis patients following the administration of tacrolimus and steroids. J Neurol Sci. 396: 30-32, 2019.
  12. Kobayashi H, Fujii K, Kobayashi M, Saito N, Okunushi K, Ebata R, Shiohama T, Sawada D, Shimojo N. Facial nerve palsy associated with atomoxetine-induced hypertension. Brain Dev. 41: 310-312, 2019.
  13. Murata Y, Kurosaka H, Ohata Y, Aikawa T, Takahata S, Fujii K, Miyashita T, Morita C, Inubushi T, Kubota T, Sakai N, Ozono K, Kogo M, Yamashiro T. A Novel PTCH1 mutation in basal cell nevus syndrome with rare craniofacial features. Hum Genome Variation. 6:16. doi: 10.1038/s41439-019-0047-9, 2019.
  14. Shiohama T, Fujii K, Miyashita T, Takatani T, Ikehara H, Uchikawa H, Motojima T, Uchida T, Shimojo N. MicroRNAs profiling in fibroblasts derived from patients with Gorlin syndrome. J Hum Genet. 64: 757-765, 2019
  15. Ibi K, Fujii K, Kobayashi H, Senda M, Kitazawa K, Honda A. Anterior cingulate cortex involvement in non-paraneoplastic limbic encephalitis. Brain Dev. 41; 731-734, 2019.
  16. Arahata Y, Fujii K, Nishimura T, Uchida T, Kitazawa K, Honda A. Longitudinal magnetic resonance imaging changes in Japanese encephalitis. Brain Dev. 41; 735-739, 2019.
  17. Inoue M, Uchino S, Iida A, Noguchi S, Hayashi S, Takahashi T, Fujii K, Komaki H, Takeshita E, Nonaka I, Okada Y, Yoshizawa T, Van Lommel L, Schuit F, Goto YI, Mimaki M, Nishino I. COX6A2 variants cause a muscle-specific cytochrome c oxidase deficiency. Ann Neurol. 86: 193-202, 2019.
  18. Shiohama T, Fujii K, Shimizu K, Ohashi H, Takatani T, Okamoto N, Nishimura G, Kato M, Shimojo N. Progressive subglottic stenosis in a child with Pallister-Killian syndrome. Congenit Anom. (Kyoto) 58: 102-104, 2018.
  19. Fukuhara T, Fujii K, Shiohama T, Shimojo N. Acute myelitis associated with human herpesvirus 7 infection. Pediatr Int. 60: 198-199, 2018.
  20. Shiohama T, Ohashi H, Shimizu K, Fujii K, Oba D, Takatani T, Kato M, Shimojo N. L-thyroxine-responsive drop attacks in childhood benign hereditary chorea: a case report. Brain Dev. 40: 353-356, 2018.
  21. Motojima T, Fujii K, Ohashi H, Arakawa H. Catathrenia in Pitt-Hopkins syndrome associated with 18q interstitial deletion. Pediatric International 60: 479-481, 2018.
  22. Sawada D, Fujii K, Misawa S, Shiohama T, Fukuhara T, Fujita M, Kuwabara S, Shimojo N. Bilateral spinal anterior horn lesions in acute motor axonal neuropathy. Brain Dev. 40: 830-832, 2018.
  23. Koga Y, Povalko N, Inoue E, Nakamura H, Ishii A, Suzuki Y, Yoneda M, Kanda F,  Kubota M, Odaka H, Fujii K. Therapeutic regimen of L-Arginine for MELAS: 9-year, prospective, multicenter, clinical research. J Neurol. 65: 2861-2874, 2018.
  24. Omata T, Fukui K, Kodama K, Watanabe Y, Aoyama H, Fujii K, Shimojo. Ocular myasthenia gravis patients following the administration of tacrolimus and steroid. J Neurol Sci. 396: 30-32, 2018.

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