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宮川 和也
（みやがわ かずや）准教授

医療・生命薬学専攻／生命薬科学専攻
所属キャンパス： 大田原キャンパス

略歴

【職歴】
国際医療福祉大学薬学部助教、講師を経て現職。博士（薬学）。
日本薬理学会学術評議員、日本神経精神薬理学会評議員、日本緩和医療薬学会評議員、日本ストレス学会理事。

学位

博士（薬学）（星薬科大学）

専門分野

神経精神薬理学、行動薬理学、漢方薬理学、エピジェネティクス、ストレス科学

担当科目

先端薬学研究特論

研究指導テーマ

①ストレス適応に関与する脳内機構の解明
②ストレス性精神疾患に対する新規薬物療法の開発
③妊娠期ストレスが子の精神発達に及ぼす影響と治療戦略の構築

自身の研究テーマ

ストレス性精神疾患の病態解明と新規治療戦略の開発

研究業績

【researchmap】
https://researchmap.jp/KZYMYGW


【論文・総説・著書】
  1. Repeated exposure to antibiotics exhibits anxiety-like behaviors with a reduction in neurogenesis in the ventral hippocampus of dentate gyrus – Neuroscience letters, (2025)
  2. Anxiolytic effects of Enterococcus faecalis 2001 on a mouse model of colitis – Scientific reports, (2024)
  3. Polarization to M1-type microglia in the hippocampus is involved in depression-like behavior in a mouse model of olfactory dysfunction – Neurochemistry international, (2024)
  4. Repeated antibiotic drug treatment negatively affects memory function and glutamatergic nervous system of the hippocampus in mice – Neuroscience letters, (2024)
  5. Upper Respiratory Symptoms as Long COVID: Insight from a Multicenter Cohort Study – OTO open, (2024)
  6. Hippocampal and gut AMPK activation attenuates enterocolitis-like symptoms and co-occurring depressive-like behavior in ulcerative colitis model mice: Involvement of brain-gut autophagy – Experimental neurology, (2023)
  7. Comprehensive analysis of long COVID in a Japanese nationwide prospective cohort study – Respiratory investigation, (2023)
  8. Possible involvement of inflammasomes on the post-stroke cognitive impairment in a mouse model of embolic cerebral infarct – Physiology & behavior, (2023)
  9. Real-world effects of once-daily inhaled steroid (fluticasone furoate) combined with long-acting beta-2 agonist (vilanterol) and long-acting muscarinic antagonist (umeclidinium) on lung function tests of asthma patients in Japan – Frontiers in Physiology, (2023)
  10. Brexpiprazole prevents colitis-induced depressive-like behavior through myelination in the prefrontal cortex – Progress in neuro-psychopharmacology & biological psychiatry, (2023)
  11. Donepezil prevents olfactory dysfunction and α-synuclein aggregation in the olfactory bulb by enhancing autophagy in zinc sulfate-treated mice – Behavioural brain research, (2022)
  12. The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force – Nature communications, (2022)
  13. DOCK2 is involved in the host genetics and biology of severe COVID-19 – Nature, (2022)
  14. Correlation between the reduction in hippocampal SirT2 expression and depressive-like behaviors and neurological abnormalities in olfactory bulbectomized mice – Neuroscience research, (2022)
  15. Possible role of transcriptional regulation of 5-HT1A receptor in the midbrain on unadaptation to stress in mice – Brain research, (2022)
  16. Antidepressant effects of Enterococcus faecalis 2001 through the regulation of prefrontal cortical myelination via the enhancement of CREB/BDNF and NF-κB p65/LIF/STAT3 pathways in olfactory bulbectomized mice – Journal of psychiatric research, (2022)
  17. Effects of smoking cessation using varenicline on the serum concentrations of oxidized high-density lipoprotein: Comparison with high-density lipoprotein cholesterol – PloS one, (2022)
  18. Trichostatin A, a histone deacetylase inhibitor, alleviates the emotional abnormality induced by maladaptation to stress in mice – Neuroscience letters, (2022)
  19. Activation of 5-HT1A receptor reduces abnormal emotionality in stress-maladaptive mice by alleviating decreased myelin protein in the ventral hippocampus – Neurochemistry international, (2021)
  20. Disturbance of prefrontal cortical myelination in olfactory bulbectomized mice is associated with depressive-like behavior – Neurochemistry international, (2021)
  21. Effects of Gadolinium Deposition in the Brain on Motor or Behavioral Function: A Mouse Model – Radiology, (2021)
  22. Recent Insights into the Measurement of Carbon Dioxide Concentrations for Clinical Practice in Respiratory Medicine – Sensors (Basel, Switzerland), (2021)
  23. Activation of cholinergic system partially rescues olfactory dysfunction-induced learning and memory deficit in mice – Behavioural brain research, (2021)
  24. ストレスリジリエンスを制御する分子メカニズムの考究 – ストレス科学, (2021)
  25. Dopamine D2 receptor supersensitivity in the hypothalamus of olfactory bulbectomized mice – Brain research, (2020)
  26. Leukemia Inhibitory Factor Participates in the Formation of Stress Adaptation via Hippocampal Myelination in Mice – Neuroscience, (2020)
  27. Antidementia effects of Enterococcus faecalis 2001 are associated with enhancement of hippocampal neurogenesis via the ERK-CREB-BDNF pathway in olfactory bulbectomized mice – Physiology & behavior, (2020)
  28. Characterization of 5-HT1A receptor and transport protein KIF13A expression in the hippocampus of stress-adaptive and -maladaptive mice – Neuroscience letters, (2020)
  29. Intermittent hypoxia, energy expenditure, and visceral adipocyte recovery – Respiratory physiology & neurobiology, (2020)
  30. Effects of Normoxic Recovery on Intima-Media Thickness of Aorta and Pulmonary Artery Following Intermittent Hypoxia in Mice – Frontiers in physiology, (2020)
  31. 【ストレス疾患とエピゲノム】ヒストンアセチル化によるストレスレジリエンスの獲得 – ストレス科学, (2019)
  32. スコポラミン誘発健忘モデルマウスにおけるドコサヘキサエン酸‒ホスファチジルセリン複合体製剤の学習記憶改善効果 – 国際医療福祉大学学会誌, (2019)
  33. Real-world efficacy and problems of once-daily use of inhaled steroid (fluticasone furoate) combined with long-acting beta-2 agonist (vilanterol) in Japanese patients with asthma – Cogent Medicine, (2019)
  34. Involvement of interleukin-31 receptor A in morphine-induced itching and antinociception in mice – European journal of pain (London, England), (2019)
  35. Effects of ginger aroma under stress conditions: a biometric perspective – Proceedings of SPIE - The International Society for Optical Engineering, (2019)
  36. Possible involvement of monoamine neurons in the emotional abnormality in Kir6.2-deficient mice – Physiology & behavior, (2018)
  37. Yokukansan, a traditional Japanese herbal medicine, enhances the anxiolytic effect of fluvoxamine and reduces cortical 5-HT2A receptor expression in mice – Journal of ethnopharmacology, (2018)
  38. EFFECTS OF ONCE-A-DAY USE OF INHALED STEROID (FLUTICASONE FUROATE) COMBINED WITH LONG-ACTING BETA-2 AGONIST (VILANTEROL) ON VARIOUS FLOW DATA IN BRONCHIAL ASTHMA – RESPIROLOGY, (2017)
  39. Inhibitory effect of yokukansan on the decrease in the hippocampal excitatory amino acid transporter EAAT2 in stress-maladaptive mice – Journal of traditional and complementary medicine, (2017)
  40. 5-HT7 receptor-mediated fear conditioning and possible involvement of extracellular signal-regulated kinase – Neuroscience letters, (2017)
  41. Prenatal stress induces vulnerability to stress together with the disruption of central serotonin neurons in mice – Nihon yakurigaku zasshi. Folia pharmacologica Japonica, (2016)
  42. Repeated administration of interleukin-31 attenuates the morphine-induced antinociceptiye tolerance in mice – Journal of Pharmacological Sciences, (2016)
  43. Repeated administration of interleukin-31 enhances the morphine-induced antinociception in mice – Journal of Pharmacological Sciences, (2016)
  44. Involvement of interleukin-31 receptor A on the morphine-induced antinociception in mice – Journal of Pharmacological Sciences, (2016)
  45. Ethanol Withdrawal-Induced Impaired Recognition Is Reversed by Chronic Exposure to Stress and the Acute Administration of Corticosterone in Mice – Biological & pharmaceutical bulletin, (2016)
  46. Herbal medicine Goshajinkigan and Rokumigan inhibit Nav1.7 voltage-gated sodium channel current – Journal of Pharmacological Sciences, (2015)
  47. Prenatal stress induces vulnerability to stress together with the disruption of central serotonin neurons in mice – Journal of Pharmacological Sciences, (2015)
  48. Assessment of behavioral phenotype in Kir6.2-deficient mice – Journal of Pharmacological Sciences, (2015)
  49. Behavioral pharmacological assessment of animal models of depression and anxiety – Journal of Pharmacological Sciences, (2015)
  50. Prenatal stress induces vulnerability to stress together with the disruption of central serotonin neurons in mice – Behavioural brain research, (2015)
  51. Repeated administration of IL-31 upregulates IL-31 receptor A (IL-31RA) in dorsal root ganglia and causes severe itch-associated scratching behaviour in mice – Experimental dermatology, (2015)
  52. Neuroprotective effect of yokukansan against cytotoxicity induced by corticosterone on mouse hippocampal neurons – Phytomedicine, (2014
  53. Varenicline-assisted smoking cessation decreases oxidative stress and restores endothelial function – Hypertension Research, (2014)
  54. Yokukansan, a traditional Japanese herbal medicine, alleviates the emotional abnormality induced by maladaptation to stress in mice – Phytomedicine, (2014)
  55. Acute Effects of Caffeine on Blood Pressure and Heart Rate in Habitual and Non-Habitual Coffee Consumers – 医療薬学, (2014)
  56. Yokukansan, a traditional Japanese herbal medicine, alleviates the anxiety-like behavior induced by prenatal restraint stress in mice – Journal of Pharmacological Sciences, (2014)
  57. Ameliorative effect of yokukansan on the emotional abnormality in stress-maladaptive mice – Journal of Pharmacological Sciences, (2014)
  58. Effects of corticosterone on the ethanol withdrawal-induced cognitive impairment in ethanol dependent mice – Journal of Pharmacological Sciences, (2014)
  59. Epigenetic regulation of resistance to emotional stress: possible involvement of 5-HT1A receptor-mediated histone acetylation – Journal of Pharmacological Sciences, (2014)
  60. Repeated exposure to stress stimuli during ethanol consumption prolongs withdrawal-induced emotional abnormality in mice – European journal of pharmacology, (2013)
  61. PREVALENCE OF DIABETES AND IMPAIRED GLUCOSE TOLERANCE IN PATIENTS WITH SLEEP APNEA SYNDROME – Respirology, (2013)
  62. The significance of hippocampal histone acetylation as a common factor involved in the development of emotional resistance and adaptation to stress in mice – Journal of Pharmacological Sciences, (2013)
  63. The influence of chronic stress stimuli on the cognitive function after the ethanol withdrawal in mice – Journal of Pharmacological Sciences, (2013)
  64. Does smoking cessation with varenicline worsen vascular endothelial function? – BMJ Open, (2013)
  65. Possible involvement of histone acetylation in the development of emotional resistance to stress stimuli – Nihon shinkei seishin yakurigaku zasshi, (2012)
  66. Role of brain 5-HT7 receptors as a functional molecule involved in the development of stress adaptation – Nihon shinkei seishin yakurigaku zasshi, (2012)
  67. Yokukansan, a traditional Japanese herbal medicine, improve the emotional abnormality induced by maladaptive to stress in mice – Journal of Pharmacological Sciences, (2012)
  68. Prenatal stress induces anxiety-like behavior together with the disruption of central serotonin neurons in mice – Neuroscience research, (2011)
  69. Possible involvement of histone acetylation on the development of emotional resistance to stress stimuli mediated by 5-HT1A receptors in mice – Journal of Pharmacological Sciences, (2011)
  70. The influence of corticosterone to glial cells proliferation and its characterization – Journal of Pharmacological Sciences, (2011)
  71. The role of 5-HT7 receptor-ERK signaling on the development of stress adaptation in mice – Journal of Pharmacological Sciences, (2011)
  72. An update on epigenetic regulation in pathophysiologies of stress-induced psychiatric disorders – Japanese Journal of Neuropsychopharmacology, (2010)
  73. Effects of Prenatal and Neonatal Exposure to Bisphenol A on the Development of the Central Nervous System – Biomolecules & Therapeutics, (2010)
  74. Possible involvement of the epigenetic regulation on the development of emotional resistance to stress stimuli in mice – Journal of Pharmacological Sciences, (2010)
  75. Protective effects of the i.c.v.injection of trichostatin A, a histone deacetylase inhibitor, against emotional changes produced by acute restraint stress in mice – Journal of Pharmacological Sciences, (2010)
  76. Possible involvement of 5-HT7 receptors on extinction learning for contextual fear memory in mice – Journal of Pharmacological Sciences, (2010)
  77. Pharmacological characterization and mechanisms of the novel antidepressive- and/or anxiolytic-like substances identified from Perillae Herba – Japanese Journal of Neuropsychopharmacology, (2008)
  78. Chronic exposure to bisphenol-A causes astrocyte activation in the mouse hippocampus – Neuroscience research, (2008)
  79. Dramatic changes in functions of the central dopaminergic system in mice perinatally exposed to bisphenol-A – Neuroscience research, (2008)
  80. DNA microarray analysis of gene expression profile in the hippocampus of mice with resistance to stress stimuli – Journal of Pharmacological Sciences, (2008)
  81. The prenatal stress induces the emotional changes together with the abnormal development of central 5-HT neurons – YAKUGAKU ZASSHI, (2008)
  82. Possible involvement of brain 5-HT7 receptors in the development of stress adaptation in mice – YAKUGAKU ZASSHI, (2008)
  83. Behavioral analysis of chronic exposure to diphenylarsinic acid associated with influence on central nervous systems – Japanese Journal of Neuropsychopharmacology, (2007)
  84. Evaluation methods for general and depressive-like behaviors – Nihon yakurigaku zasshi. Folia pharmacologica Japonica, (2007)
  85. Changes in central dopaminergic systems and morphine reward by prenatal and neonatal exposure to bisphenol-A in mice: evidence for the importance of exposure period – Addiction Biology, (2007)
  86. Memory impairment associated with a dysfunction of the hippocampal cholinergic system induced by prenatal and neonatal exposures to bisphenol-A – Neuroscience Letters, (2007)
  87. Changes in central dopaminergic systems with the expression of Shh or GDNF in mice perinatally exposed to bisphenol-A – Japanese Journal of Neuropsychopharmacology, (2007)
  88. Involvement of inflammatory pathway in methamphetamine-induced neurotoxicity – YAKUGAKU ZASSHI, (2007)
  89. Changes in central dopaminergic neuron development with expression of sonic hedgehog (Shh) or glial cell line-derived neurotrophic factor (GDNF) in mice prenatally and neonatally exposed to bisphenol-A – Journal of Pharmacological Sciences, (2007)
  90. Effect of acute treatment with neuron/astrocyte conditioned medium activated by the stimulation of 5-HT1A receptor on the anxiolytic behavior – Journal of Pharmacological Sciences, (2007)
  91. Prenatal and neonatal exposure to low-dose of bisphenol-A enhance the morphine-induced hyperlocomotion and rewarding effect – Neuroscience Letters, (2006)
  92. Dynamic changes in dopaminergic neurotransmission induced by a low concentration of bisphenol-A in neurones and astrocytes – Journal of Neuroendocrinology, (2006)
  93. The role of glia cells on the dopaminergic neurobehavioral toxicity induced by exposure to bisphenol-A – Neuroscience research, (2006)
  94. Functional role of the glial cells in the induction of stress – Neuroscience research, (2006)
  95. Exposure to bisphenol-A affects the rewarding system in mice – Japanese Journal of Neuropsychopharmacology, (2005)
  96. The functional change in the 5-HT1A receptor induced by stress and the role of the 5-HT1A receptor in neuroprotection – Japanese Journal of Neuropsychopharmacology, (2005)
  97. Prenatal and neonatal exposure to bisphenol-A affects the morphine-induced rewarding effect and hyperlocomotion in mice – Neuroscience Letters, (2004)
【主な学会賞】
  1. 国際医療福祉大学学会　第9回国際医療福祉大学学会学術大会優秀発表賞 2019年
    胎生期ストレスが惹起する脳内ヒストン修飾変化の網羅的解析
  2. 日本ストレス学会 本ストレス学会奨励賞（高田賞）2018年
    胎生期ストレスが惹起する不安感受性の亢進と抑肝散の治療効果
  3. 国際医療福祉大学学会　第8回国際医療福祉大学学会学術大会優秀発表賞 2018年
    胎生期ストレスが惹起する後天的ストレス脆弱性のエピジェネティクス制御メカニズム
  4. 日本薬学会 体機能と創薬シンポジウム2008 秀ポスター賞 2008年
    胎生期ストレス刺激による中枢5-HT神経の発達異常と情動変化
【主な外部資金獲得】
  1. 学研究費　基盤研究（C）（研究代表者）「低酸素誘導因子を基軸としたストレス適応能への妊娠期低酸素曝露の影響と抑肝散の応用」（2025年度 - 2027年度）
  2. 科学研究費　基盤研究（C）（研究代表者）「妊娠期の低酸素状態が子の情動的ストレス応答に及ぼす影響と抑肝散の治療効果」（2022年度 - 2024年度）
  3. 科学研究費　基盤研究（C）（研究代表者）「妊娠期のストレス曝露が誘発する子の情動障害に対する抑肝散の治療メカニズムの解明」（2019年度 - 2021年度）
  4. 科学研究費　若手研究（B）（研究代表者）「妊娠期のストレス曝露が誘発する子の情動障害に対する抑肝散の応用」（2016年度 - 2018年度）

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