国際医療福祉大学大学院

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大越 絵実加

大越 絵実加
（おおこしえみか）教授

医療・生命薬学専攻／生命薬科学専攻
所属キャンパス： 大田原キャンパス

略歴

【学歴】

博士（薬学）日本大学
修士（薬学）日本大学
学士（薬学）日本大学

【職歴】

青森大学薬学部薬学科教授
青森大学薬学部薬学科准教授
明海大学歯学部MPL研究教育助教
Research assistant professor temporary University of North Carolina at Chapel Hill
奥羽大学薬学部助手
株式会社キリンビール基盤技術研究所（横浜）研究員
株式会社エイエルエイ中央研究所 研究員
日本大学薬学部生薬学研究室助手

【資格】

薬剤師、危険物取扱者（甲種および乙種第4類）

専門分野

生薬学／天然物化学、科学教育

担当科目

基礎薬学総合特論

研究指導テーマ

天然物由来成分の生物活性の探索

研究業績

【researchmap】

https://researchmap.jp/eohkoshi
ORCID ID：0000-0001-9700-9973

【主な原著論文】
  1. Horimatsu S., Mizutani M., Miura H, Ohkoshi E. A Hands-on Experiment of Caffeine Extraction from Tea Leaves using Direct Sublimation: Learning Effectiveness for Secondary School Students. Journal of Chemical Education (2025)
  2. Kusama EK., Tokui Y., Minoura A., Yanai Y., Hirose D., Furukawa M., Kosuge Y., Miura M., Ohkoshi E, Makino M., Minagawa K., Matsuzaki K., Ogawa Y., Watanabe K., Ohsaki A. 2(3H)-Dihydrofranolactone metabolites from Pleosporales sp. NUH322 as anti-amyotrophic latera sclerosis sclerosis drugs. Journal of Natural Medicines, 78:146–159 (2024)
  3. Ohkoshi E, Horimatsu S., Tada T, Hitomi K., Nogami M., Ishii K. Proton-induced X-ray emission analysis of white birch milk. International Journal of PIXE, 30, No. 03n04, 85–89 (2022)
  4. Murakami K., Umemura N., Adachi M., Motoki M., Ohkoshi E. ABCG2, CD44 and SOX9 are increased with the acquisition of drug resistance and involved in cancer stem cell activities in head and neck squamous cell carcinoma cells. Experimental and Therapeutic Medicine, 24: 722 (2022)
  5. Wada K, Goto M, Ohkoshi E, Lee KH, Yamashita H. Bioactivity inspired C19-diterpenoid alkaloids for overcoming multidrug-resistant cancer. Journal of Natural Medicines, 76: 796–802 (2022)
  6. Kajiura T, Umemura N, Ohkoshi E, Ohta T, Kondoh N, Kawano S. Shikonin induces odontoblastic differentiation of dental pulp stem cells via AKT–mTOR signaling in the presence of CD44. Connective Tissue Research, 12: 1-9 (2021)
  7. Nanbu T., Umemura N., Ohkoshi E, Nanbu K., Sakagami H., Shimada J. Combined SN-38 and gefitinib treatment promotes CD44 degradation in head and neck squamous cell carcinoma cells. Oncology Reports, 39:367-375 (2018)
  8. Sumi S., Umemura N., Takayama E., Ohkoshi E, Adachi M., Mizuno-Kamiya M., Inagaki T., Kawaki H., Sumitomo S., Kondoh N. Metastasized murine oral squamous cell carcinoma cells induce intratumoral polymorphonuclear myeloid derived suppressor cells. Oncology Reports, 37: 2897-2904 (2017)
  9. Ohkoshi E and Umemura N. Induced overexpression of CD44 associated with resistance to apoptosis on DNA damage response in human head and neck squamous cell carcinoma cells. International Journal of Oncology, 50: 387-395 (2017)
  10. Nakagawa-Goto K., Taniguchi Y., Watanabe Y., Oda A., Ohkoshi E, Hamel E., Lee K.H., Goto M. Triethylated chromones with substituted naphthalenes as tubulin inhibitors. Bioorganic & Medicinal Chemistry, 24: 6048-6057 (2016)
  11. Umemura N., Ohkoshi E, Tajima M., Kikuchi H., Katayama T., Sakagami H. Hyaluronan induces odontoblastic differentiation of dental pulp stem cells via CD44. Stem Cell Research & Therapy, 7:135-47 (2016)
  12. Wang SB, Cui M.T., Wang X.F., Ohkoshi E, Goto M., Yang D.X., Li L., Yuan S., Morris-Natschke S.L., Lee K.H., Xie L. Synthesis, biological evaluation, and physicochemical property assessment of 4-substituted 2-phenylaminoquinazolines as Mer tyrosine kinase inhibitors. Bioorganic & Medicinal Chemistry, 24:3083-92 (2016)
  13. Wang SB, Wang XF, Qin B, Ohkoshi E, Hsieh KY, Hamel E, Cui MT, Zhu DQ, Goto M, Morris-Natschke SL, Lee KH, Xie L. Optimization of N-aryl-6-methoxy-1,2,3,4-tetrahydroquinolines as tubulin polymerization inhibitors. Bioorganic & Medicinal Chemistry, 23: 5740-5747 (2015)
  14. Wada K, Ohkoshi E, Zhao Y, Goto M, Morris-Natschke SL, Lee KH. Evaluation of Aconitum diterpenoid alkaloids as antiproliferative agents. Bioorganic & Medicinal Chemistry Letters, 25:1525-31 (2015)
  15. Nakagawa-Goto K, Oda A, Hamel E, Ohkoshi E, Lee KH, Goto M. Development of a Novel Class of Tubulin Inhibitor from Desmosdumotin B with a Hydroxylated Bicyclic B-Ring. Journal of Medicinal Chemistry, 58: 2378-2389 (2015)

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