教員紹介 TEACHING STAFF
教員情報

久保田 紀子
(くぼた のりこ)教授
保健医療学専攻 臨床検査学分野
所属キャンパス: 大田原キャンパス
略歴
【職歴】
- 聖マリアンナ医科大学付属病院
- 長野県立こども病院
- 長野県松本保健所
- 地方独立行政法人長野県立こども病院
学位
- 信州大学医療短期大学部衛生技術学科 卒業
- 学位授与機構 学士(保健衛生学)
- 信州大学工学系研究科 大学院修士(農学)
- 信州大学工学系研究科 大学院博士(工学)
専門分野
- 臨床微生物学
担当科目
臨床検査学講義Ⅰ・Ⅱ 臨床検査学演習Ⅰ・Ⅱ
研究指導テーマ
- 新生児における常在菌叢-目指すべき常在菌叢モデルの確立‐
- マイクロバイオーム研究への臨床検体活用と解析前プロセスの課題解決
- 臨床分離株解析へのWhole-genome sequencingデータの活用
大学院入学希望者に望むこと
大学院では、疾患の細胞学的特徴を追求するため、免疫組織化学染色や遺伝子検査に基づいた解析により形態学的検索を行う意義や技術を理解し、病態解析ができる応用能力を身に付けてほしいと思います。加えて、得られた研究成果を報告することにより、積極的に様々な分野の研究者との考察を深め、連携し、学問的創造性に貢献できる人材となってほしいと考えています。
探究心を持ち主体的に研究に参加することで、私たちの研究チームの目的である“子宮頸がんや上皮内腫瘍で苦しむ女性を減らす”ことに一緒に貢献していきましょう。
研究業績
【researchmap】
https://researchmap.jp/kubota_noriko
【論文】(英文のみ)
- Kobayashi J, Ohkusu M, Matsumoto T, Kubota N, Ishiwada N. Bacteriological and molecular characterization of temperature- and CO2-dependent Streptococcus pneumoniae serotype 24F ST162 isolated from Japanese children. Microbiol Spectr. 2023 Dec 12;11(6):e0216523.
- Kubota N, Takeda R, Kobayashi J, Hidaka E, Nishi E, Takano K, Wakui K. Chromosomal microarray data reanalysis using a smaller CNV call threshold identified four cases with heterozygous multiexon deletions of the ARID1B, EHMT1, and FOXP1 genes. Microbiol Spectr. 2023 Dec 12;11(6):e0216523.
- Nasuno M, Yokoyama Y, Motobayashi M, Kobayashi K, Omori N, Murai T, Kubota N, Kitamura M, Minami K, Inaba Y. Targeted temperature management at 36°C is a risk factor for ventilator-associated pneumonia. Pediatr Int. 2023 Jan-Dec;65(1):e15556.
- Kobayashi J, Takezawa Y, Saito S, Kubota N, Sakashita K, Nakazawa Y, Higuchi Y, Tozuka M, Ishida F. Immature Platelet Fraction and Its Kinetics in Neonates. J Pediatr Hematol Oncol. 2023 Mar 1;45(2):e249-e253.
- Kasai A, Kobayashi J, Nishioka M, Kubota N, Inaba Y, Motobayashi M. Early Phase Increase in Serum TIMP-1 in Patients with Acute Encephalopathy with Biphasic Seizures and Late Reduced Diffusion. Children (Basel). 2022 Dec 30;10(1):78.
- Kubota N, Kobayashi J, Kasai A, Nasuno M, Murai T, Minami K, Ohta M. Detection of Bacillus cereus as a causative agent of emetic food poisoning by an unconventional culture procedure. J Infect Chemother. 2022 Nov;28(11):1575-1577.
- Konno S, Yanagisawa R, Kubota N, Ogiso Y, Nishimura N, Sakashita K, Tozuka M. Investigation of patient factors associated with the number of transfusions required during chemotherapy for high-risk neuroblastoma. Vox Sang. 2022 Jan;117(1): 71-79.
- Uchida E, Kurata T, Komori K, Kobayashi J, Kubota N, Sakashita K. Sequential Therapy of Inotuzumab Ozogamicin and Blinatumomab as a Bridge-to Hematopoietic Stem Cell Transplantation in a Pediatric Patient With Primary Refractory Acute Lymphoblastic Leukemia: A Case Report. Pediatr Int. 2021 Oct; 63(10):1260-1261.
- Minami K, Murai T, Omori N, Kasai A, Kubota N. Informative: Case report and review of Klebsiella oxytoca bacteremia in a pediatric hospital. Pediatr Int. 2021 Oct;63(10):1260-1261.
- Higuchi T, Yoshizawa K, Hatata T, Yoshizawa K, Takamizawa S, Kobayashi J, Kubota N, Hidaka E. Novel Causative RET Mutation in a Japanese Family with Hirschsprung's Disease: Case Report and Factors Impacting Disease Severity. J Pediatr Genet. 2020 Oct 5;11(3):240-244.
- Thanh Nha Uyen L, Amano Y, Al-Kzayer LFY, Kubota N, Kobayashi J, Nakazawa Y, Koike K, Sakashita K. PCDH17 functions as a common tumor suppressor gene in acute leukemia and its transcriptional downregulation is mediated primarily by aberrant histone acetylation, not DNA methylation. Int J Hematol. 2020 Mar;111(3):451-462.
- Ide Y, Yanagisawa R, Kubota N, Sakashita K, Tozuka M, Nakamura T, Honda T. Analysis of the clinical characteristics of pediatric patients who experience ifosfamide-induced encephalopathy. Pediatr Blood Cancer. 2019 Dec;66(12):e27996.
- Kobayashi J, Yanagisawa R, Ono T, Tatsuzawa Y, Tokutake Y, Kubota N, Hidaka E, Sakashita K, Kojima S, Shimodaira S, Nakamura T. Administration of platelet concentrates suspended in bicarbonated Ringer's solution in children who had platelet transfusion reactions. Vox Sang. 2018 Feb;113(2):128-135.
- Yanagisawa R, Kubota N, Hidaka E, Sakashita K, Tanaka M, Nakazawa Y, Nakamura T. Cisplatin-induced nephrotoxicity in patients with advanced neuroblastoma. Pediatr Blood Cancer. 2018 Sep;65(9):e27253.
- Minami K, Terakawa R, Sato M, Shoji Y, Hiroma T, Nakamura T, Horiuchi A, Otsuka A, Kubota N, Hidaka E, Kawakami Y, Aung MS, Kobayashi N. A Colonization Outbreak of Penicillin-Susceptible mecA-Positive Staphylococcus aureus in a Neonatal Ward of Children's Hospital. Infect Control Hosp Epidemiol. 2018 Feb;39(2):239-241.
- Shimada K, Yanagisawa R, Kubota N, Hidaka E, Sakashita K, Ishii E, Matsuura S, Ogiso Y Wilms tumor accompanied by premature chromatid separation. Pediatr Blood Cancer. 2017 Mar;64(3)
- Yanagisawa R, Minami K, Kubota N, Iwade T, Ogiso Y. Asymptomatic subcutaneous cervical mass due to Actinomyces odontolyticus infection in a pyriform sinus fistula. Pediatr Int. 2017 Aug;59(8):941-942.
- Cho Y, Minami K, Kasai M, Kubota N, Higuchi T Infective endocarditis due to multiple species of anaerobes following tricuspid valve replacement. J Microbiol Immunol Infect. 2017 Oct;50(5):733-734.
- Sato M, Kubota N, Katsuyama Y, Suzuki Y, Miyairi Y, Minami K, Kasai M A 6-year-old girl with Mycoplasma hominis ventriculoperitoneal shunt infection. J Neurosurg Pediatr. 2017 May;19(5):620-624
- Minami K, Yasuda R, Terakawa R, Koike Y, Takeuchi K, Higuchi T, Horiuchi A, Kubota N, Hidaka E, Kawakami Y. Four sporadic pediatric cases of Yersinia enterocolitica O:8 infection in rural area of Japan. Jpn J Infect Dis. 2017 Mar 24;70(2):192-194.
- Nishi E, Masuda K, Arakawa M, Kawame H, Kosho T, Kitahara M, Kubota N, Hidaka E, Katoh Y, Shirahige K, Izumi K Exome sequencing-based identification of mutations in non-syndromic genes among individuals with apparently syndromic features. Am J Med Genet A. 2016 Nov;170(11):2889-2894
- Sato M, Kubota N, Horiuchi A, Kasai M, Minami K, Matsui H. Frequency, clinical manifestations, and outcomes of Staphylococcus lugdunensis Bacteremia in children. J Infect Chemother. 2016 May;22(5):298-302
- Domon H, Uehara Y, Oda M, Seo H, Kubota N, Terao Y. Poor survival of Methicillin-resistant Staphylococcus aureus on inanimate objects in the public spaces. Microbiologyopen. 2016 Feb;5(1):39-46.
- Izumi K, Hayashi D, Grochowski C, Kubota N, Nishi E, Arakawa M, Hiroma T, Hatata T, Ogiso Y, Nakamura T, Falsey AM, Hidaka E,Spinner NB Discordant clinical phenotype in monozygotic twins with Alagille syndrome: Possible influence of non-geneticfactors. American Journal of Medical Genetics Part A :. 2016 Feb;170A(2):471-475.
- Horiuchi A, Kubota N, Hidaka E, Nakamura T, Oana K, Kawakami Y A Case of Pediatric Pertussis Unhesitatingly Diagnosed with the Insight of Microbiology Laboratory British Journal of Medicine & Medical Research 16(12): 1-4, 2016, Article no.BJMMR.27175
- Horiuchi A, Kubota N, Hidaka E, Shimabukuro A, Yasukochi S, Nakamura T, Oana K, Kawakami Y. Notable alkaline tolerance of Kocuria marina isolate from blood of a pediatric patient with continuous intravenous epoprostenol therapy. J Infect Chemother. 2015 Sep;21(9):680-6.
- Yanagisawa R, Ishii E, Motoki N, Yamazaki S, Morita D, Sakashita K, Shiohara M, Tanaka M, Hidaka Y, Kubota N, Hidaka E, Ogiso Y, Nakamura T, Yasukochi S. Pretransplant-corrected QT dispersion as a predictor of pericardial effusion after pediatric hematopoietic stem cell transplantation. Transpl Int. 2015 May;28(5):565-74
- Izumi K, Kubota N, Arakawa M, Takayama M, Harada Y, Nakamura T, Nishi E, Hidaka E. Dissecting the Phenotype of Supernumerary Marker Chromosome 20 in a patient with Syndromic Pierre Robin Sequence: Combinatorial Effect of Gene Dosage and Uniparental Disomy. Am J Med Genet A. 2015 Jun;167(6):1289-93.
- Minami K, Higuchi T, Cho Y, Koike Y, Takeuchi K, Kubota N, Hidaka E, Horiuchi A, Kawakami Y. Proportion of Rectal Carriage of Extended-Spectrum β-Lactamase-Producing Enterobacteriaceae in the Inpatients of a Pediatric Tertiary Care Hospital in Japan. Jpn J Infect Dis. 2012;65(6):548-50.
- Kubota N, Kuzumoto K, Hidaka E, Yoshizawa K, Yumoto K, Oana K, Ogiso Y, Nakamura T, Kawakami Y. First Isolation of Oleate-Dependent Enterococcus faecalis Small-Colony Variants from an Umbilical Exudate of a Pediatric Patient with Omphalitis. J Med Microbiol. 2013 Dec;62(Pt 12):1883-1890.
- Minami K, Shoji Y, Kasai M, Ogiso Y, Nakamura T, Kawakami Y, Saito Y, Kuzumoto K, Kubota N, Yumoto K, Ishii K. Proportion of Rectal Carriage of Extended-Spectrum β-Lactamase-Producing Enterobacteriaceae in the Inpatients of a Pediatric Tertiary Care Hospital in Japan. Jpn J Infect Dis. 2012;65(6):548-50.
- Kuzumoto K, Kubota N, Ishii K, Yumoto K, Ogiso Y, Nakamura T, Katsuyama T, Oana K, Kawakami Y. Successful cessation of transmitting healthcare-associated infections due to Bukhoderia cepacia complex in a neonatal intensive care unit in a Japanese children hospital. Eur J Med Res. 2011 Dec 2;16(12):537-42.
- Nakata S, Yasui K, Nakamura T, Kubota N, Baba A. Perfluorocarbon suppresses lipopolysaccharide- and α-toxin-induced interleukin-8 release from alveolar epithelial cells. Neonatology. 2007;91(2):127-33.
- Takagi K, Unno N, Hyodo HE, Hyodo H, Kashima H, Kubota N, Ogiso Y, Noike M, Itoh K, Shiobara S, Konishi I, Saito S. Complete hydatidiform mole in a triplet pregnancy coexisting two viable fetuses: Case report and review of the literature. Journal of Obstetric Gynaecology Research, vol.29, No5, 330-338, 2003
- Hirabayashi S, Shiobara J, Iwasaki Y, Ogiso Y, Kubota N, Oka A, Takashima S. Chronic meningoencephalitis due to cytomegalovirus infection in a nonimmunocompromised patient: an autopsy case. J Child Neurol. 1998 Nov;13(11):570-3.
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