Innovation & Research Support Center
Celebrating its 30th anniversary, our university has entered a new phase of growth. In addition to supporting clinical and translational research, this center will also provide support for our university's unique basic medical research.
Professor Kazuhiro Ogata, Director of Innovation & Research Support Center
Professor of School of Medicine
- Biography
- Graduated from Yokohama City University School of Medicine (M.D.) and completed postgraduate studies at its Graduate School of Medical Science (Ph.D.).
- Career Highlights
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- Research Scientist, RIKEN
- Laboratory Head, KAST Ogata "Protein Function Regulation Project"
- Professor and Head of the Department of Biochemistry, Yokohama City University School of Medicine
- Director of the Yokohama City University Library and Chairman of the National, Public, and Private University Libraries Cooperation Committee
- Head of the Integrated Basic Medical Sciences Division, School of Medicine, Yokohama City University
- Head of the Medical Ethics and Research Placement Division, School of Medicine, Yokohama City University
- Head of the Examination Management and National Medical Examination Preparation Division, School of Medicine, Yokohama City University
- Head of the Doctoral Program, Graduate School of Medical Science, Yokohama City University
- Dean of the Graduate School of Medical Science, Yokohama City University
- Current and Future Positions
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- Professor Emeritus, Yokohama City University (effective 2025)
- Professor and Director of Academic Affairs, International University of Health and Welfare (effective 2025)
- Selected Publications
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- Solution structure of a DNA-binding unit of Myb: A helix-turn-helix-related motif with conserved tryptophan forming a hydrophobic core／Ogata K, Hojo H, Aimoto S, Nakai T, Nakamura H, Sarai A, Ishii S, Nishimura Y－Proc Natl Acad Sci USA (1992, 89(14): 6428-6432)
- Solution structure of a specific DNA complex of the Myb DNA-binding domain with cooperative recognition helices／Ogata K, Morikawa S, Nakamura H, Sekikawa A, Inoue T, Kanai H, Sarai A, Ishii S, Nishimura Y－Cell (1994, 79(4): 639-648)
- Solution structure of the c-Myb DNA-binding domain: Comparison between the free and DNA-complexed forms／Ogata K, Morikawa S, Nakamura H, Hojo H, Yoshimura S, Zhang R, Aimoto S, Ametani Y, Hirata Z, Sarai A, Ishii S, Nishimura Y－Nature Struct Biol (1995, 2(4): 309-320)
- The cavity in the hydrophobic core of the Myb DNA-binding domain reserved for DNA-recognition and trans-activation／Ogata K, Kanei-Ishii C, Sasaki M, Hatanaka H, Nagadoi A, Enari M, Nakamura H, Nishimura Y, Ishii S, Sarai A－Nature Struct Biol (1996, 3(2): 178-187)
- Structural analyses of DNA recognition by the AML1/Runx-1 Runt domain and its allosteric control by CBFβ／Tahirov TH, Inoue T, Sasaki M, Kimura K, Morii H, Fujikawa A, Shiina M, Sato K, Kumasaka T, Yamamoto M, Ishii S, Ogata K－Cell (2001, 104(5): 755-767)
- Mechanism of c-Myb-C/EBPβ cooperation from separated sites on a promoter／Tahirov TH, Sato K, Ichikawa-Iwata E, Sasaki M, Inoue-Bungo T, Shiina M, Kimura K, Takata S, Fujikawa A, Morii H, Kumasaka T, Yamamoto M, Ishii S, Ogata K－Cell (2002, 108(1): 57-70)
- Eukaryotic transcriptional regulatory complexes: cooperativity from near and afar／Ogata K, Sato K, Tahirov TH－Curr Opin Struct Biol (2003, 13(1): 40-48)
- De novo mutations in the gene encoding STXBP1 (MUNC18-1) cause early infantile epileptic encephalopathy／Saitsu H, Kato M, Mizuguchi T, Hamada K, Osaka H, Tohyama J, Uruno K, Kumada S, Nishiyama K, Nishimura A, Okada I, Yoshimura Y, Hirai S, Kumada T, Hayasaka K, Fukuda A, Ogata K, Matsumoto N－Nature Genet (2008, 40(6): 782-788)
- A novel allosteric mechanism on protein-DNA interactions underlying the phosphorylation-dependent regulation of Ets1 target gene expressions／Shiina M, Hamada K, Inoue-Bungo T, Shimamura M, Uchiyama A, Baba S, Sato K, Yamamoto M, Ogata K－J Mol Biol (2015, 427(8): 1655-1669)
- Phosphorylation of an intrinsically disordered region of Ets1 shifts a multi-modal yields a specific interaction ensemble to among many multi-modal interactions an auto-inhibitory state／Kasahara K, Shiina M, Higo J, Ogata K, Nakamura H－Nucleic Acids Res (2018, 46(5): 2243-2251)
- Structural basis of the regulation of normal and oncogenic methylation of nucleosomal histone H3 Lys36 by NSD2／Sato K, Kumar A, Hamada K, Okada C, Oguni A, Machiyama A, Sakuraba S, Nishizawa T, Nureki O, Kono H, Ogata K, Sengoku T－Nature Commun (2021, 12(1): 6605)
- Structural basis of transcription regulation by CNC family transcription factor, Nrf2／Sengoku T, Shiina M, Suzuki K, Hamada K, Sato K, Uchiyama A, Kobayashi S, Oguni A, Itaya H, Kasahara K, Moriwaki H, Watanabe C, Honma T, Okada C, Baba S, Ohta T, Motohashi H, Yamamoto M, Ogata K－Nucleic Acid Res (2022, 50(21): 12543-12557)
- Structure of the human Bre1 complex bound to the nucleosome／Onishi S, Uchiyama K, Sato K, Okada C, Kobayashi S, Hamada K, Nishizawa T, Nureki O, Ogata K, Sengoku T－Nature Commun (2024, 15(1): 25802024)
- A p.N92K variant of the GTPase RAC3 disrupts cortical neuron migration and axon elongation／Sugawara R, Hamada K, Ito H, Scala M, Ueda H, Tabata H, Ogata K, Nagata KI－J Biol Chem (2025 Apr; 301(4): 108346)