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北島 道夫

北島 道夫
(きたじま みちお)教授

医学研究科 医学専攻
所属キャンパス: 大川キャンパス

略歴

長崎大学医学部附属病院産婦人科医員
日赤長崎原爆病院産婦人科医員
国立長崎中央病院NICUローテート
長崎大学医学部附属病院麻酔科ローテイト
五島中央病院産婦人科医員
長崎大学医学部歯学部附属病院産婦人科助教
ベルギー・ルーヴァンカトリック大学サンリュック病院婦人科客員研究員
長崎大学病院産婦人科講師
長崎大学大学院医歯薬学総合研究科産科婦人科准教授

学位

博士(医学)(長崎大学)

専門分野

産婦人科
生殖内分泌学、女性医学、婦人科腫瘍学、周産期医学

担当科目

産婦人科学特論Ⅰ~Ⅳ
医学特別研究Ⅰ~Ⅳ

研究指導テーマ

生殖内分泌学
不妊症、生殖補助医療、思春期婦人科学、更年期医学、エストロゲン依存性疾患(子宮内膜症・子宮腺筋症・子宮筋腫)、妊孕性温存、婦人科低侵襲性手術

研究業績

【researchmap】
https://researchmap.jp/myshanKita


<著書>

  1. 1.Kitajima M. Chapter 12 - Endometriosis and ovarian dysfunction. In Kaori Koga Eds, Immunology of Endometriosis Pathogenesis and Management, Reproductive Immunology. Academic press, 2022, pp 193-201.
  2. 2.Kitajima M. Ovarian reserve in patients with endometriosis. In: Harada T eds. Endometriosis: Pathogenesis and Treatment. Japan: The Springer publishing, 2014.

<論文>

  1. 1.Kitajima M, Kajimura I, Kitajima Y, Murakami N, Matsumura A, Matsumoto K, Harada A, Hasegawa Y, Miura K. AMH producing purely cystic virilizing adult granulosa cell tumor in 17 years old girl: a case report and review of literatures. J Ovarian Res. 2023 Mar 15;16(1):52. doi: 10.1186/s13048-023-01134-0.
  2. 2.Kitajima M, Murakami N, Kitajima Y, Kajimura I, Matsumura A, Matsumoto K, Harada A, Miura K. Accumulation of fibrosis and altered perifollicular stromal differentiation in vitrified-thawed human ovarian tissue xenografted to nude mice. Reprod Med Biol. 2022 Mar 10;21(1):e12451. doi: 10.1002/rmb2.12451. eCollection 2022 Jan-Dec.
  3. 3.Kitajima M , Matsumoto K, Kajimura I, Harada A, Miyashita N, Matsumura A, Kitajima Y, Miura K. The Effects of Endometriosis on Ovarian Functions. Endocrines 2021, 2(2), 142-149 https://doi.org/10.3390/endocrines2020014
  4. 4.Kitajima M , Matsumoto K, Murakami N, Kajimura I, Harada A, Kitajima Y, Masuzaki H, Miura K. AMH concentrations in peritoneal fluids of women with and without endometriosis. Front Surg. 2020 Nov 11;7:600202. doi: 10.3389/fsurg.2020.600202. eCollection 2020.
  5. 5.Kitajima M , Matsumoto K, Murakami N, Harada A, Kitajima Y, Masuzaki H, Miura K. Ovarian reserve after three-step laparoscopic surgery for endometriomas utilizing dienogest: a pilot study. Reprod Med Biol. 2020 Sep 13;19(4):425-431. doi: 10.1002/rmb2.12349. eCollection 2020 Oct.
  6. 6.Murakami N, Kitajima M, Ohyama K, Aibara N, Taniguchi K, Wei M, Kitajima Y, Miura K, Masuzaki H. Comprehensive immune complexome analysis detects disease-specific immune complex antigens in seminal plasma and follicular fluids derived from infertile men and women. Clin Chim Acta. 2019 Aug;495:545-551. doi: 10.1016/j.cca.2019.05.031.
  7. 7.Noguchi M, Kitajima M, Abe S, Murakami N, Kitajima Y, Miura K, Masuzaki H. Huge uterine fibroid arising fron primary uterine cervical diverticulum: a case report and review of the literatures. J Obstet Gynaecol. 2019 Nov;39(8):1186-1187. Doi: 10.1080/01443615.2019.1588237.
  8. 8.Kitajima M, Murakami N, Taniguchi K, Kitajima Y, Tsukamoto O, Miura K, Masuzaki H. Histomorphological aspects of the ovarian cortex regarding ovarian reserve and local pelvic inflammation. J. Mamm. Ova Res. Vol. 35 (1), 21–26, 2018.
  9. 9.Kitajima M, Miura K, Inoue T, Murakami Y, Kitajima Y, Murakami N, Taniguchi K, Yoshiura KI, Masuzaki H. Two consecutive successful live birth in woman with 17α hydroxylase deficiency by frozen-thaw embryo transfer under hormone replacement endometrium preparation. Gynecol Endocrinol. 2018 May;34(5):381-384. doi: 10.1080/09513590.2017.1393512. Epub 2017 Oct 25.
  10. 10.Kitajima M, Khan KN, Harada A, Taniguchi K, Inoue T, Kaneuchi M, Miura K, Masuzaki H. Association between ovarian endometrioma and ovarian reserve. Front Biosci (Elite Ed). 2018 Jan 1;10:92-102. doi: 10.2741/e810.
  11. 11.Inoue T, Kitajima M, Taniguchi K, Masuzaki H. Three-dimensional saline-infusion sonohysterography is useful for the identification of endometrial polyp. J Obstet Gynaecol Res 42:855-9,2016.
  12. 12.Khan KN, Kitajima M, Hiraki K, Fujishita A, Nakashima M, Masuzaki H. Decreased expression of human heat shock protein 70 in the endometria and pathological lesions of women with adenomyosis and uterine myoma after GnRH agonist therapy. Eur J Obstet Gynecol Reprod Biol 187:6-13,2015.
  13. 13.Khan KN, Kitajima M, Hiraki K, Fujishita A, Nakashima M, Masuzaki H. Involvement of hepatocyte growth factor-induced epithelial-mesenchymal transition in human adenomyosis. Biol Reprod. 2015 Feb;92(2):35. doi: 10.1095/biolreprod.114.124891. Epub 2014 Dec 10.
  14. 14. Khan KN, Kitajima M, Inoue T, Fujishita A, Nakashima M, Masuzaki H. 17β-estradiol and lipopolysaccharide additively promote pelvic inflammation and growth of endometriosis. Reprod Sci 22:585-94,2015.
  15. 15.Khan KN, Kitajima M, Hiraki K, Fujishita A, Nakashima M, Masuzaki H. Visible and occult microscopic lesions of endometriosis. Gynecology and Minimally Invasive Therapy, Vol. 3, Issue 4, p109–114, Published online: January 19, 2015.
  16. 16.Kitajima M, Dolmans MM, Donnez O, Masuzaki H, Soares M, Donnez J. Enhanced follicular recruitment and atresia in cortex derived from ovaries with endometriomas. Fertil Steril. 2014 Apr;101(4):1031-7. doi: 10.1016/j.fertnstert.2013.12.049. Epub 2014 Feb 4.
  17. 17.Khan KN, Kitajima M, Fujishita A, Nakashima M, Masuzaki H. Toll-like receptor system and endometriosis (review). J Obstet Gynecol Res 39(8):1281-92,2013.
  18. 18.Khan KN, Kitajima M, Inoue T, Tateishi S, Fujishita A, Nakashima M, Masuzaki H. Additive effects of inflammation and stress reaction on Toll-like receptor 4-mediated growth of endometriotic stromal cells. Hum Reprod 28:2794-2803,2013.
  19. 19.Khan KN, Kitajima M, Fujishita A, Hiraki K, Matsumoto A, Nakashima M, Masuzaki H. Pelvic pain in women with ovarian endometrioma is mostly associated with coexisting peritoneal lesions. Hum Reprod 28(1):109-118,2013.
  20. 20. Jadoul P, Kitajima M, Donnez O, Squifflet J, Donnez J. Surgical treatment of ovarian endometriomas: state of the art? Fertil Steril. 2012 Sep;98(3):556-63. doi: 10.1016/j.fertnstert.2012.06.023. Epub 2012 Jul 3.
  21. 21.Khan KN, Kitajima M, Yamaguchi N, Fujishita A, Nakashima M, Ishimaru T, Masuzaki H. Role of prostaglandin E2 in bacterial growth in women with endometriosis. Hum Reprod 27:3417-3424,2012.
  22. 22.Kitajima M, Defrére S, Dolmans MM, Colette S, Squifflet, J Van Langendonkt A, Donnez J. Endometrioma as a possible cause of reduced ovarian reserve in women with endometriosis. Fertil Steril. 2011 Sep;96(3):685-91. doi: 10.1016/j.fertnstert.2011.06.064. Epub 2011 Jul 29.
  23. 23.Kitajima M, Khan KN, Hiraki K, Inoue T, Fujishita A, Masuzaki H. Changes in serum anti- Müllerian hormone levels may predict damage to residual normal ovarian tissue after laparoscopic surgery for women with ovarian endometrioma. Fertil Steril. 2011 Jun 30;95(8):2589-91.e1. doi: 10.1016/j.fertnstert.2011.01.036. Epub 2011 Feb 10.
  24. 24.Khan KN, Kitajima M, Hiraki K, Yamaguchi N, Katamine S, Matsuyama T, Fujishita A, Nakashima M, Ishimaru T, Masuzaki H. Escherichia coli contamination of menstrual blood and effect of bacterial endotoxin on endometriosis. Fertil Steril. 2010 Dec;94(7):2860-3.e1-3. doi: 10.1016/j.fertnstert.2010.04.053.
  25. 25.Khan KN, Kitajima M, Hiraki K, Fujishita A, Nakashima M, Ishimaru T, Masuzaki H. Cell proliferation effect of GnRH agonist on pathologic lesions of women with endometriosis, adenomyosis and uterine myoma. Hum Reprod 25: 2878-2890,2010.
  26. 26.Khan KN, Kitajima M, Hiraki K, Fujishita A, Sekine I, Ishimaru T, Masuzaki H. Changes in tissue inflammation, angiogenesis and apoptosis in endometriosis, adenomyosis and uterine myoma after GnRH agonist therapy. Hum Reprod. 2010 Mar;25(3):642-53. doi: 10.1093/humrep/dep437. Epub 2009 Dec 15.
  27. 27.Khan KN, Kitajima M, Hiraki K, Fujishita A, Sekine I, Ishimaru T, Masuzaki H. Effect of human seminal fluid on the growth of endometrial cells of women with endometriosis. Eur J Obstet Gynecol Reprod Biol. 149:204-209,2010.
  28. 28.Khan KN, Kitajima M, Hiraki H, Fujishita A, Sekine I, Ishimaru T, Masuzaki H. Toll-like receptors in innate immunity: role of bacterial endotoxin and toll-like receptor 4 (TLR4) in endometrium and endometriosis. Gynecol Obstet Invest (review article) 68:40-52,2009.
  29. 29.Khan KN, Kitajima M, Hiraki H, Fujishita A, Sekine I, Ishimaru T, Masuzaki H. Immunopathogenesis of pelvic endometriosis: role of hepatocyte growth factor, macrophages and ovarian steroids. Am J Reprod Immunol. 2008 Nov;60(5):383-404. doi: 10.1111/j.1600-0897.2008.00643.x.
  30. 30.Khan KN, Kitajima M, Imamura T, Hiraki K, Fujishita A, Sekine I, Ishimaru T, Masuzaki H. Toll-like receptor 4 (TLR4)-mediated growth of endometriosis by human heat shock protein 70 (Hsp70). Hum Reprod 23:2210-2219,2008.
  31. 31.Khan KN, Kitajima M, Fujishita A, Ishimaru T, Sekine I, Masuzaki H. Multifunctional role of hepatocyte growth factor in the development of pelvic endometriosis. WES e-journal (review article), July:13-20, 2008.
  32. 32.Kitajima M, Khan KN, Fujishita A, Masuzaki H, Koji T, Ishimaru T. Expression of the arylhydrocarbon receptor in the peri-implantation period of the mouse uterus and the impact of dioxin on mouse implantation. Arch Histol Cytol. 2004 Dec;67(5):465-74. doi: 10.1679/aohc.67.465.
  33. 33.Kitajima M, Khan KN, Fujishita A, Masuzaki H, Ishimaru T. Histomorphometric alteration and cell-type specific modulation of arylhydrocarbon receptor and estrogen receptor expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin and 17ß-estradiol in mouse experimental model of endometriosis. Reprod Toxicol. 2004 Aug-Sep;18(6):793-801. doi: 10.1016/j.reprotox.2004.04.012.
  34. 34.Kitajima M, Oka S, Yasuhi I, Fukuda M, Rii Y, Ishimaru T. Maternal serum triglyceride at 24--32 weeks' gestation and newborn weight in nondiabetic women with positive diabetic screens. Obstet Gynecol. 2001 May;97(5 Pt 1):776-80. doi: 10.1016/s0029-7844(01)01328-x.

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