GRADUATE SCHOOL

GRADUATE SCHOOL

Departments

Graduate School of Medicine/Graduate School of Public Health

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Staff Information

Tatsuo Shimosawa

M.D., Ph.D., FAHA
Graduate School of Medicine, Affiliation Campus: Narita

Profile (Career Summary)

He received M.D. degree from Tsukuba Univesity and PhD degree from the Tokyo University.
He completed his residency at the Tokyo University hospital and appointed as assistant professor of Endocrinology and Nephrology Dept and lecturer of Clinical Laboratory medicine of the Tokyo University.
In 2017 he is appointed as the professor and chief of Clinical Laboratory medicine of IUHW and in 2018, professor of graduate school of IUHW. He is a board certificate by internal medicine, clinical laboratory, hypertension, endocrinology and gerontology.
His research interests are epigenetic control of blood pressure and its related organ damages. Also in clinical research he conducts several trials to find new biomarkers in non-communicable diseases.
Besides his professional work, he is the vice president of Japanese Clarinet Association.
He has been accepting PhD candidates from all over the world for more than a decade and his lab official language is English. He welcomes those who has the desire to explore unsolved question in medicine.

References

  1. Shimosawa T, Ito Y, Ando K, Kitamura K, Kangawa K, Fujita T.
    Proadrenomedullin NH2-terminal 20 peptide, a new product of the adrenomedullin gene, inhibits norepinephrine overflow from nerve endings.
    J Clin Invest. 96:1672-1676, 1995.
  2. Shimosawa T, Shibagaki Y, Ishibashi K, Kitamura K, Kangawa K, Kato S, Ando K, Fujita T.
    Adrenomedullin, an Endogenous Peptide, Counteracts Cardiovascular Damage.
    Circulation. 105:106-111, 2002.
  3. Mu S, Shimosawa T, Ogura S, Wang H, Uetake Y, Kawakami-Mori F, Marumo T, Yatomi Y, Geller DS, Tanaka H, Fujita T.
    Epigenetic modulation of the renal β-adrenergic-WNK4 pathway in salt-sensitive hypertension.
    Nat Med. 17:573–580, 2011.
  4. Shibata S, Mu S, Kawarazaki H, Muraoka K, Ishizawa K, Yoshida S, Kawarazaki W, Takeuchi M, Ayusawa N, Miyoshi J, Takai Y, Ishikawa A, Shimosawa T, Ando K, Nagase M, Fujita T.
    Rac1 GTPase in rodent kidneys is essential for salt-sensitive hypertension via a mineralocorticoid receptor-dependent pathway.
    J Clin Invest. 121:3233-3243, 2011.
  5. Shukuya K, Ogura S, Tokuhara Y, Okubo S, Yatomi Y, Tozuka M, Shimosawa T.
    Novel Round Cells in Urine Sediment and Their Clinical Implications.
    Clinica Chimica Acta. 457:142-9, 2016.
  6. Yasukawa K, Shimosawa T, Okubo S, Yatomi Y.
    A simple, rapid, and validated high-performance liquid chromatography method suitable for clinical measurements of human mercaptalbumin and nonmercaptalbumin.
    Ann Clin Biochem.1:4563217693257. doi: 10.1177/0004563217693257,2017.
  7. Tokuhara Y, Shukuya K, Tanaka M, Sogabe K, Ejima Y, Hosokawa S, Ohsaki H,  Morinishi T, Hirakawa E, Yatomi Y, Shimosawa T.
    Absorbance measurements of oxidation of homogentisic acid accelerated by the addition of alkaline solution with sodium hypochlorite pentahydrate.
    Sci Rep, 2018 in press