GRADUATE SCHOOL

Departments

Graduate School of Medicine/Graduate School of Public Health

Staff Information

Makoto Sugaya

M.D.,Ph.D.
Graduate School of Medicine, Affiliation Campus: Narita

Specialized Field

cutaneous lymphoma, atopic dermatitis, chemokine, lymphatics, Langerhans cells

Message to Students

I have much experience with writing English papers and teaching foreign students or residents. I would like to help you to be a physician scientist who can work around the world.

Research Project

Immunology and tumor microenvironment of cutaneous lymphoma
Development of diagnostic tools and treatment strategies for cutaneous lymphoma
Biomarkers and mechanisms of itch in atopic dermatitis
Role of lymphatics in cutaneous immunity

References

  1. Oka T, et al. CXCL17 attenuates imiquimod-induced psoriasis-like skin inflammation by recruiting myeloid-derived suppressor cells and regulatory T cells. J Immunol 198:3897-3908, 2017.
  2. Takahashi N, et al. Thymic stromal chemokine TSLP acts through Th2 cytokine production to induce cutaneous T cell lymphoma. Cancer Res76:6241-6252, 2016.
  3. Suga H, et al. Skin barrier dysfunction and low antimicrobial peptide expression in cutaneous T-cell lymphoma. Clin Cancer Res 20: 4339-4348, 2014.
  4. Suga H, et al. CXCR3 deficiency prolongs Th1-type contact hypersensitivity. J Immunol 190:6059-6070, 2013.
  5. Morimura S, et al. Interaction between CX3CL1 and CX3CR1 regulates vasculitis induced by immune complex deposition. Am J Pathol 182:1640-1647, 2013.
  6. Miyagaki T, et al. IL-22, but not IL-17, dominant environment in cutaneous T cell lymphoma. Clin Cancer Res 17: 7529-7538, 2011.
  7. Miyagaki T, et al. CCL11-CCR3 interactions promote survival of anaplastic large cell lymphoma cells via ERK1/2 activation. Cancer Res 71: 2056-2065, 2011.
  8. Sugaya M, et al. Oncostatin M enhances CCL21 expression by microvascular endothelial cells and increases the efficiency of dendritic cell trafficking to lymph nodes. J Immunol 177:7665-7672, 2006.
  9. Sugaya M, et al. Lymphatic dysfunction in transgenic mice expressing KSHV k-cyclin under the control of the VEGFR-3 promoter. Blood 105: 2356-2363, 2005.
  10. Sugaya M, et al. HIV-infected Langerhans cells preferentially transmit virus to proliferating autologous CD4+ memory T cells located within Langerhans cell-T cell clusters. J Immunol 172:2219-2224, 2004.