GRADUATE SCHOOL

Departments

Graduate School of Medicine/Graduate School of Public Health

Staff Information

Yosuke Osawa

M.D.,Ph.D.
Graduate School of Medicine, Affiliation Campus:

Profile

Education:
Ph.D. Gifu University graduate school of medicine, Japan
M.D. Gifu University school of medicine, Japan

Professional and academic positions:
Professor of Gastroenterology, IUHW school of medicine
Professor, IUHW hospital
Chief physician, Division of medical information for hepatic diseases, The research center for hepatitis and immunology, National center for global health and medicine, Japan
Chief physician, Tokyo metropolitan cancer and infectious diseases center Komagome hospital, Japan
Assistant professor, Department of pharmacology, Gifu University school of medicine, Japan
Research associate, Department of informative medicine, Gifu University school of medicine, Japan
Fellow physician, Department of internal medicine, Gifu University hospital, Japan
Post doctoral fellow, Department of medicine, Columbia university, USA.

Research interests

Liver cancer, Liver fibrosis, and Hepatic and gastrointestinal diseases.

Mechanisms of liver fibrosis induced by chronic liver congestion; Lipid signaling on non-alcoholic steatohepatitis; Treatment of hepatocellular carcinoma by anti-PD-1 antibody in mice; Treatment of liver fibrosis by beta-catenin inhibitor in mice; Treatment of liver cirrhosis patients with HCV infection by beta-catenin inhibitor; Treatment of metastatic liver cancer by ceramide induction in mice; Roles of sphingolipid signals liver fibrosis.

References

  1. Osawa Y, Kawai H, Tsunoda T, Komatsu H, Okawara M, Tsutsui Y, Yoshida Y, Yoshikawa S, Mori T, Yamazoe T, Yoshio S, Oide T, Inui A, KantoT. Cluster of differentiation 44 promotes liver fibrosis and serves as a biomarker in congestive hepatopathy. Hepatol Commun. 5, 1437, 2021.
  2. Osawa Y, Oboki K, Imamura J, Kojika E, Hayashi Y, Hishima T, Saibara T, Shibasaki F, Kohara M, Kimura K. Inhibition of Cyclic Adenosine Monophosphate (cAMP)-response Element-binding Protein (CREB)-binding Protein (CBP)/β-Catenin Reduces Liver Fibrosis in Mice. EBioMedicine, 2, 1751–1758, 2015.
  3. Osawa Y, Suetsugu A, Matsushima-Nishiwaki R, Yasuda I, Saibara T, Moriwaki H, Seishima M, Kozawa O. Liver acid sphingomyelinase inhibits growth of metastatic colon cancer. J Clin Invest. 123, 834-843, 2013.
  4. Osawa Y, Kanamori H, Seki E, Hoshi M, Ohtaki H, Yasuda Y, Ito H, Suetsugu A, Nagaki M, Moriwaki H, Saito K, Seishima M. L-Tryptophan-mediated enhancement of susceptibility to nonalcoholic fatty liver disease is dependent on the mammalian target of rapamycin. J Biol Chem. 286, 34800-34808, 2011.
  5. Osawa Y, Seki E, Adachi M, Suetsugu A, Ito H, Moriwaki H, Seishima M, Nagaki M. Role of acid sphingomyelinase of Kupffer cells in cholestatic liver injury in mice. Hepatology. 51, 237-245, 2010.
  6. Seki E, De Minicis S, Osterreicher CH, Kluwe J, Osawa Y, Brenner DA, Schwabe RF. TLR4 enhances TGF-β signaling and hepatic fibrosis. Nat Med. 13, 1324-1332, 2007.
  7. Osawa Y, Hannun, YA, Proia RL, Brenner DA. Roles of AKT and sphingosine kinase in the antiapoptotic effects of bile duct ligation in mouse liver. Hepatology. 42, 1320-1328, 2005.