GRADUATE SCHOOL

GRADUATE SCHOOL

Departments

Graduate School of Medicine/Graduate School of Public Health

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Staff Information

Ryuji Fukuzawa

MD, PhD
Affiliation Campus：Narita

Specialized Field

Paediatric and Developmental Pathology, Molecular Oncology

Message to Students

Students and researchers who are interested in embryonic growth and development, cell differentiation, fetal and paediatric diseases are very much welcome.

Research Theme

My research focuses on the molecular pathology of tumours that recapitulate early embryogenesis and organogenesis (e.g., germ cell tumours, embryonal tumours) and their precursor lesions (developmental abnormalities occurring during the embryogenesis). To clarify molecular mechanisms of their tumorigenesis and developmental programmes, I am using not only molecular techniques (microarray, CGH, Exosome DNA sequencing etc.) but also pathologic and epidemiologic approaches as part of international collaborations. I am also analysing the histological changes of iPS cells transplanted into immunodeficient mice.

References

  1. Fukuzawa, Anaka, et al. The developmental programme for genesis of the entire kidneyis recapitulated in Wilms tumour. PLoS One. 2017; 12:e0186333.
  2. Sugai, Fukuzawa, et al. Pathological classification of human iPSC-derived neural stem/progenitor cells towards safety assessment of transplantation therapy for CNS diseases. Mol Brain. 2016 ;9:85.
  3. Fukuzawa, Holman, et al. WTX mutations can occur both early and late in the pathogenesis of Wilms tumour.
    1. J Med Genet. 2010 ;47:791-4.
  4. Fukuzawa, Anaka, et al. Canonical WNT signaling determines lineage specificity in Wilms tumour. Oncogene. 2009 ;28:1063-75.
  5. Jenkins, van Kogelenberg, et al. Germline mutations in WTX cause a sclerosing skeletal dysplasia but do not predispose to tumorigenesis. Nat Genet. 2009 ;41:95-100
  6. Fukuzawa, Anaka, et al. Wilms tumour histology is determined by distinct types of precursor lesions and not epigenetic changes. J Pathol. 2008 ;215:377-87.
  7. Fukuzawa, Breslow, et al. Epigenetic differences between Wilms' tumours in white and east-Asian children. Lancet. 2004;363:446-51.