Graduate School of Medicine/Graduate School of Public Health
Staff Information
Yasuhiko Tomita
MD, PhD
Affiliation Campus：Narita
Specialized Field
Human pathology
Message to Students
Correlation of molecules in ubiquitin-proteasome pathway with tumor grade is now focused. Let’s start to make new therapeutic strategies against cancer together.
Research Theme
I have revealed that molecules in ubiquitin-proteasome pathway have a relationship with cancer grade and metastasis. Now I am working on the involvement of these molecules in STAT3 and NFκB pathways.
References
- Tomita, et al. Histologic grading in soft-tissue sarcomas. An analysis of 194 cases including AgNOR count and mast-cell count. Int J Cancer. 1993; 54:194-9.
- Asai, Tomita, et al. VCP (p97) regulates NFkappaB signaling pathway, which is important for metastasis of osteosarcoma cell line. Jpn J Cancer Res. 2002; 93:296-304.
- Yamamoto, Tomita, et al. Elevated expression of valosin-containing protein (p97) in hepatocellular carcinoma is correlated with increased incidence of tumor recurrence. J Clin Oncol. 2003; 21:447-52.
- Qiu et al. Pre-B-cell leukemia transcription factor 1 regulates expression of valosin-containing protein, a gene involved in cancer growth. Am J Pathol. 2007; 170:152-9.
- Wang, et al. GdX/UBL4A specifically stabilizes the TC45/STAT3 association and promotes dephosphorylation of STAT3 to repress tumorigenesis. Mol Cell. 2014; 53:752-65.