GRADUATE SCHOOL

GRADUATE SCHOOL

Departments

Graduate School of Medicine/Graduate School of Public Health

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Staff Information

Shinichi Murase

MD, PhD
Affiliation Campus：Narita

Profile (Career Summary)

Assistant Professor at the Department of Anatomy, Keio University School of Medicine, Tokyo.
Research Associate at the Department of Cell and Structural Biology, University of Illinois at Urbana-Champaign.
Staff Scientist at the Department of Cell Biology, University of Virginia, Charlottesville.
Associate Professor at the Division of Pharmacology, Niigata University, Graduate School of Medical and Dental Sciences, School of Medicine, Niigata.
Professor at the Department of Pharmacology, International University of Health and Welfare, School of Medicine, Narita.

Specialized Field

pharmacology, cell biology, neuroscience

Message to Students

Carl Gegenbaur said that “Nature always gives us answers, if only we know how to ask questions correctly.” Although experimental techniques for asking nature are gradually changing with the times, both the quality of the questions and the enthusiasm for unraveling the questions will affect the course of research at all times. Pharmacology is “a treasure trove of unsolved questions”. We are surprised at the fact that it is not unusual to know the mechanisms of action of drugs that have been used for decades are not elucidated, and impressed with the fact that a new academic field would be opened when the mechanism of action of such drugs is solved. We assist young people who are interested in life science and are going to open up their futures in the academic world.

Research Theme

drug receptors, G-protein coupled receptor (GPCR), cell adhesion molecules, extracellular matrix, neurogenesis, neural migration and differentiation


References

  1. Murase, S., Shiiya, T. and Higuchi, H. (2017). Neuropeptide Y Y5 receptor localization in mouse central nervous system. Brain Research, 1655, 216-232.
  2. Murase, S., Cho, C., White, J.M. and Horwitz, A.F. (2008). ADAM2 promotes migration of neuroblasts in the rostral migratory stream to the olfactory bulb. European Journal of Neuroscience, 27, 1585-1595.
  3. Carbonell, WS., Murase, S., Horwitz, A.F. and Mandell, J.W. (2005). Migration of perilesional microglia after focal brain injury and modulation by CC chemokine receptor 5: An in situ time-lapse confocal imaging study. Journal of Neuroscience, 25, 7040-7047.
  4. Murase, S., and Horwitz, A.F. (2004). Directions in cell migration along the rostral migratory stream: The pathway for migration in the brain. Current Topics in Developmental Biology, 61, 135-152.
  5. Murase, S., and Horwitz, A.F. (2002). Deleted in colorectal carcinoma and differentially expressed integrins mediate the directional migration of neural precursors in the rostral migratory stream. Journal of Neuroscience, 22, 3568-3579.
  6. Murase, S., and Hayashi, Y. (1998). Expression pattern and neurotrophic role of the c-fms proto-oncogene M- CSF receptor in rodent Purkinje cells. Journal of Neuroscience, 18, 10481-10492.
  7. Murase, S., and Hayashi, Y. (1998). Concomitant expression of genes encoding integrin alphavbeta5 heterodimer and vitronectin in growing parallel fibers of postnatal rat cerebellum: A possible role as mediators of parallel fiber elongation. Journal of Comparative Neurology, 397, 199-212.
  8. Murase, S., and Hayashi, Y. (1998). Integrin alpha1 localization in murine central and peripheral nervous system. Journal of Comparative Neurology, 395, 161-176
  9. Murase, S., and Hayashi, Y. (1996). Expression pattern of integrin beta1 subunit in Purkinje cells of rat and cerebellar mutant mice. Journal of Comparative Neurology, 375, 225-237.