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Staff Information

Motoo Kitagawa

MD, PhD
Affiliation Campus：Narita

Specialized Field

Biochemistry, Molecular Biology

Message to Applicants

I wish to organize a laboratory that carries out both in vitro structural/functional analyses of proteins and their biological analyses with genetically modified mice. I also wish to promote collaborations with both domestic and foreign researchers having different expertise. Notch signaling plays pivotal roles for both normal differentiation/developmental processes and various pathological processes including tumor development. I am looking for students, who wish to join the research.

Research Theme

Mechanisms of cellular signal transduction (especially Notch signaling)

References

1. Masuda, et al. Enhanced surface presentation and activation of Notch1 by transmembrane 2 domain containing 3, a mammalian homologue of Drosophila neurogenic gene product Almondex.  Submitted.
2. Toritsuka, et al. Regulation of striatal dopamine responsiveness by Notch/RBP-J signaling. Transl. Psychiatry 7, e1049,2017.
3. Kitagawa M. Notch signaling in the nucleus: roles of Mastermind-like transcriptional coactivators. J. Biochem. 159, 287-294, 2016.
4. Muroyama, et al. Olfactory sensory neurons control dendritic complexity of mitral cells via Notch signaling. PLOS Genet. 12, e1006514, 2016.
5. Watanabe, et al. MAML1 enhances the transcriptional activity of Runx2 and plays a role in bone development. PLOS Genet. 9, e1003132, 2013.
6. Oyama, et al. Mastermind-like 1 (MamL1) and mastermind-like 3 (MamL3) are essential for Notch signaling in vivo.  Development 138, 5235-5246, 2011.
7. Köchert, et al. High-level expression of Mastermind-like 2 contributes to aberrant activation of the NOTCH signaling pathway in human lymphomas. Oncogene 30, 1831-1840, 2011.
8. Sasaki, et al. The repression of Notch signaling occurs via the destabilization of mastermind-like 1 by Mesp2 and is essential for somitogenesis. Development 138, 55-64, 2011.
9. Ishitani, et al. Nemo-like kinase suppresses Notch signalling by interfering with formation of the Notch active transcriptional complex. Nature Cell Biol. 12, 278-285, 2010.
10. Fukami, et al. Mastermind-like domain containing 1 (MAMLD1 or CXorf6) transactivates the Hes3 promoter, augments testosterone production, and contains the SF1 target sequence. J. Biol. Chem. 283, 5525-5532, 2008.
11. Oyama, et al.  Mastermind-1 is required for Notch signal-dependent steps in lymphocyte development in vivo. Proc. Natl. Acad. Sci. U.S.A. 104, 9764-9769, 2007.
12. Ishikawa, et al. Notch deficiency implicated in the pathogenesis of congenital disorder of glycosylation IIc. Proc. Natl. Acad. Sci. U.S.A. 102, 18532-18537, 2005.
13. Sasamura, et al. Neurotic, a novel maternal neurogenic gene, encodes an O-fucosyltransferase that is essential for Notch–Delta interactions. Development 130, 4785-4795, 2003.
14. Lin, et al. Identification of new human mastermind proteins defines a family that consists of positive regulators for Notch signaling. J. Biol. Chem. 277, 50612-50620, 2002.
15. Kitagawa, et al. A human protein with sequence similarity to Drosophila Mastermind coordinates the nuclear form of Notch and a CSL protein to build a transcriptional activator complex on target promoters. Mol. Cell. Biol. 21, 4337-4346, 2001.