Graduate School of Medicine/Graduate School of Public Health
Staff Information
Takayuki Shiomi
MD, PhD
Affiliation Campus：Narita
Profile (Career Summary)
1998 M.D., Keio University, School of Medicine (Tokyo, Japan)
1998-2002 Keio University, Graduate School of Medicine (Tokyo, Japan)
2002-2007 Instructor of Pathology, Keio University, School of Medicine (Tokyo, Japan)
2007-2010 Postdoctoral Research Fellow, Columbia University, College of Physicians and Surgeons (New York, NY, USA)
2010–2015 Associate Research Scientist, Columbia University, College of Physicians and Surgeons (New York, NY, USA)
2015-2017 Research Scientist, New York University Langone Medical Center (New York, NY, USA)
2017- Professor, Department of Pathology, IUHW, School of Medicine (Narita, Chiba, Japan)
2018- Director, Center for Basic Medical Sciences at Narita Campus, IUHW
Specialized Field
Experimental pathology (Cellular communications and extracellular matrix metabolism), Diagnostic Pathology (Pulmonary pathology)
Research Theme
Our laboratory focuses on the analysis of cellular communications and ECM metabolism in pulmonary diseases and development of their manipulation as therapeutic targets
Message to Applicants
We are interested in cellular communications and ECM metabolism as the driving forces which cause morphological changes in diseases. We use various methodology from biochemistry/molecular biology study to analysis of animal models and human specimen, and even mathematical models to solve this complex puzzle. We envision to evolve morphology from the knowledge from experiences to the prediction of molecular behavior.
References
- Ueno, Shiomi, et al. ADAM9 is over-expressed in human ovarian clear cell carcinomas and suppresses cisplatin-induced cell death. Cancer Sci. 2018; 109: 471-482.
- D'Armiento, Shiomi, et al. Mesenchymal Tumorigenesis Driven by TSC2 Haploinsufficiency Requires HMGA2 and Is Independent of mTOR Pathway Activation. Cancer Res. 2016; 76: 844-854.
- Carver, et al. Mmp1a and Mmp1b Are Not Functional Orthologs to Human MMP1 in Cigarette Smoke-induced Lung Disease. Exp Toxicol Pathol. 2015; 67:153-159.
- Shiomi, et al. SFRP1 Maintains the Pluripotential State of Bronchial Alveolar Stem Cells and Regulates Proliferation Post Injury. FASEB J. 2014; 28:5242-5249.
- Elkington, Shiomi, et al. MMP-1 drives immunopathology in human tuberculosis and transgenic mice. J Clin Invest. 2011; 121:1827–1833.
- Shiomi, et al. Pericellular activation of proMMP-7 (promatrilysin-1) through interaction with CD151. Lab Invest. 2005; 85:1489-1506.